{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:50Z","timestamp":1787016170573,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and objective<\/jats:title>\n Bronchiectasis is a growing health burden both globally and in Australasia. Associated with repeated respiratory infections, the disease often results in hospital admission, impaired quality of life, reduced lung function and shortened life expectancy. We describe the local clinical, physiological and sputum characteristics in patients hospitalized with an infective exacerbation of bronchiectasis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This study examined the medical records of all 61 adults admitted to a metropolitan Australian hospital with an infective exacerbation of bronchiectasis in a calendar year.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Baseline characteristics include: mean (\n SD<\/jats:styled-content>\n ) age of participants was 66 (14) years; 56% were women and 42% were current or ex\u2010smokers. The majority had other coexisting medical conditions, with asthma in 44%,\n COPD<\/jats:styled-content>\n in 59% and both asthma and\n COPD<\/jats:styled-content>\n in 31%. Seventy\u2010two percent were on regular inhaled medication, 23% on cyclical antibiotics and 26% undertook regular respiratory physiotherapy. Bronchodilator reversibility was present in 17% and small airway reversibility in 41%. Sputum demonstrated normal flora in 17%,\n Pseudomonas aeruginosa<\/jats:italic>\n in 32%,\n Haemophilus influenzae<\/jats:italic>\n in 15% and both organisms in 17%. Mean numbers of exacerbations per year requiring hospitalization was 2.3. Sixty\u2010two percent of subjects had an Index of Relative Socio\u2010Economic Disadvantage in deciles 1\u20135. Risk factors for exacerbations included a history of asthma or\n COPD<\/jats:styled-content>\n , documented small airway reversibility and presence of\n P. aeruginosa<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Patients hospitalized with an infective exacerbation of bronchiectasis are predominantly older with co\u2010morbidities and of lower socio\u2010economic status. Presence of\n P. aeruginosa<\/jats:italic>\n was a risk factor for repeated exacerbations, as was a history of asthma,\n COPD<\/jats:styled-content>\n or small airway reversibility.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.13005","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T22:52:38Z","timestamp":1487976758000},"page":"922-927","source":"Crossref","is-referenced-by-count":21,"title":["Patients hospitalized with an infective exacerbation of bronchiectasis unrelated to cystic fibrosis:\n C<\/scp>\n linical, physiological and sputum characteristics"],"prefix":"10.1111","volume":"22","author":[{"given":"Victoria","family":"Venning","sequence":"first","affiliation":[{"name":"Department of Medicine Prince of Wales Hospital Sydney New South Wales Australia"},{"name":"Department of Respiratory Medicine Western Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Western Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lata","family":"Jayaram","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Western Health Melbourne Victoria Australia"},{"name":"Melbourne Medical School Western Precinct, University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.00287"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"PasteurMC BiltonD HillAT;British Thoracic Society Bronchiectasis non\u2010CF Guideline Group. British Thoracic Society guideline for non\u2010CF bronchiectasis.Thorax2010; (65 Suppl. 1): i1\u201358.","DOI":"10.1136\/thx.2010.136119"},{"key":"e_1_2_7_4_1","article-title":"Factors associated with mortality in hospitalised patients with bronchiectasis [abstract]","volume":"189","author":"Lim A","year":"2014","journal-title":"Am. J. Respir. Crit. 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