{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:21:22Z","timestamp":1789611682225,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Ministry of Health"},{"name":"L'Association de Recherche SYNAPSE"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>\n<jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content>\n<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Clinical and epidemiological cohort studies have shown that obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>) is a common but largely undiagnosed disorder in senior subjects, where progressive deterioration of the pathology would be expected as a consequence of the ageing processes. Our study examines the longitudinal progression of <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> over a 7\u2010year period in a community\u2010based sample of healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sample consisted of 284 volunteers, aged &gt;65\u2009years (52% women, 48% men) accepting clinical and instrumental follow\u2010up at 7\u2009years. <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> was defined as an apnoea\u2013hypopnoea index (<jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>) of \u226515.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between evaluations in the total sample, <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> slightly decreased from 17.8\u2009\u00b1\u200914 to 16.7\u2009\u00b1\u200911 with a decrease affecting more the hypopnoea index (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and associated with significant changes (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in all indices of hypoxaemia. While in the non\u2010<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> group there was a slight but significant increase of <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>, a significant <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> decrease was noted in mild\u2010moderate patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and a significant rise of nocturnal hypoxaemia in severe <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> decrease was not associated with clinical, weight, metabolic and blood pressure changes between the two evaluations; the baseline <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> value being the only factor correlated to the degree of <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In elderlies, the severity and prevalence of <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> decrease progressively with ageing without effect of factors commonly influencing <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> severity. This trend may support the hypothesis that in healthy elderly, <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> is a phenomenon related to ageing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13013","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T12:06:39Z","timestamp":1487765199000},"page":"1007-1014","source":"Crossref","is-referenced-by-count":17,"title":["A 7\u2010year follow\u2010up study of obstructive sleep apnoea in healthy elderly: <scp>T<\/scp>he <scp>PROOF<\/scp> cohort study"],"prefix":"10.1111","volume":"22","author":[{"given":"Emilia","family":"Sforza","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Centre VISAS, CHU Nord University Hospital of Saint Etienne, EA 4607 SNA EPIS, University of Lyon (UDL), Jean Monnet University  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hupin","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Centre VISAS, CHU Nord University Hospital of Saint Etienne, EA 4607 SNA EPIS, University of Lyon (UDL), Jean Monnet University  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Pichot","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Centre VISAS, CHU Nord University Hospital of Saint Etienne, EA 4607 SNA EPIS, University of Lyon (UDL), Jean Monnet University  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Claude","family":"Barth\u00e9l\u00e9my","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Centre VISAS, CHU Nord University Hospital of Saint Etienne, EA 4607 SNA EPIS, University of Lyon (UDL), Jean Monnet University  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Roche","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Centre VISAS, CHU Nord University Hospital of Saint Etienne, EA 4607 SNA EPIS, University of Lyon (UDL), Jean Monnet University  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01290.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.486"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/31.2.241"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","unstructured":"YoungT ShaharE NietoJ RedlineS NewmanAB GottliebDJ WalslebenJA FinnL EnrightP SametJM;Sleep Heart Health Study Research Group. 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