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Achieving better asthma control in this group of patients is therefore of key importance. Systematic assessment of patients with possible severe asthma to identify treatment barriers and triggers of asthma symptoms, including co\u2010morbidities, improves asthma control and reduces healthcare costs and is recommended by international guidelines on management of severe asthma.<\/jats:p>\n                  <jats:p>\n                    This review provides the clinician with an overview of the prevalence and clinical impact of the most common co\u2010morbidities in severe asthma, including chronic rhinosinusitis, nasal polyposis, allergic rhinitis, dysfunctional breathing, vocal cord dysfunction, anxiety and depression, obesity, obstructive sleep apnoea syndrome (\n                    <jats:styled-content style=\"fixed-case\">OSAS<\/jats:styled-content>\n                    ), gastroesophageal reflux disease (\n                    <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>\n                    ), bronchiectasis, allergic bronchopulmonary aspergillosis (\n                    <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content>\n                    ) and eosinophilic granulomatous with polyangiitis (\n                    <jats:styled-content style=\"fixed-case\">EGPA<\/jats:styled-content>\n                    ). Furthermore, the review offers a summary of recommended diagnostic and management approaches for each co\u2010morbidity. Finally, the review links co\u2010morbid conditions to specific phenotypes of severe asthma, in order to guide the clinician on which co\u2010morbidities to look for in specific patients.\n                  <\/jats:p>","DOI":"10.1111\/resp.13026","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T06:29:02Z","timestamp":1490250542000},"page":"651-661","source":"Crossref","is-referenced-by-count":214,"title":["Co\u2010morbidities in severe asthma:\n                    <scp>C<\/scp>\n                    linical impact and management"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4825-9436","authenticated-orcid":false,"given":"Celeste","family":"Porsbjerg","sequence":"first","affiliation":[{"name":"Respiratory Research Unit, Department of Respiratory Medicine Bispebjerg University Hospital  Copenhagen Denmark,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Menzies\u2010Gow","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,22]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.05.005"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.04.014"},{"key":"e_1_2_15_4_1","first-page":"1","article-title":"From the global strategy for asthma management and prevention, Global Initiative for Asthma (GINA) 2012","author":"Global Initiative for Asthma","year":"2012","journal-title":"Glob. 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