{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:21:19Z","timestamp":1791948079293,"version":"4.3.4"},"reference-count":68,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NHMRC-funded Centre for Research Excellence"},{"name":"Centre for Air quality and health Research and evaluation (CAR)"},{"name":"Wellcome Trust Postdoctoral Training Fellowship for Clinicians","award":["104553\/z\/14\/z"],"award-info":[{"award-number":["104553\/z\/14\/z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>\n                    <jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content>\n                  <\/jats:title>\n                  <jats:p>\n                    Coal workers\u2019 pneumoconiosis (\n                    <jats:styled-content style=\"fixed-case\">CWP<\/jats:styled-content>\n                    ), as part of the spectrum of coal mine dust lung disease (\n                    <jats:styled-content style=\"fixed-case\">CMDLD<\/jats:styled-content>\n                    ), is a preventable but incurable lung disease that can be complicated by respiratory failure and death. Recent increases in coal production from the financial incentive of economic growth lead to higher respirable coal and quartz dust levels, often associated with mechanization of longwall coal mining. In Australia, the observed increase in the number of new\n                    <jats:styled-content style=\"fixed-case\">CWP<\/jats:styled-content>\n                    diagnoses since the year 2000 has necessitated a review of recommended respirable dust exposure limits, where exposure limits and monitoring protocols should ideally be standardized. Evidence that considers the regulation of engineering dust controls in the mines is lacking even in high\u2010income countries, despite this being the primary preventative measure. Also, it is a global public health priority for at\u2010risk miners to be systemically screened to detect early changes of\n                    <jats:styled-content style=\"fixed-case\">CWP<\/jats:styled-content>\n                    and to include confirmed patients within a central registry; a task limited by financial constraints in less developed countries. Characteristic\n                    <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\n                    \u2010ray changes are usually categorized using the International Labour Office classification, although future evaluation by low\u2010dose\n                    <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content>\n                    ) chest scanning may allow for\n                    <jats:styled-content style=\"fixed-case\">CWP<\/jats:styled-content>\n                    detection and thus avoidance of further exposure, at an earlier stage. Preclinical animal and human organoid\u2010based models are required to explore potential re\u2010purposing of anti\u2010fibrotic and related agents with potential efficacy. Epidemiological patterns and the assessment of molecular and genetic biomarkers may further enhance our capacity to identify susceptible individuals to the inhalation of coal dust in the modern era.\n                  <\/jats:p>","DOI":"10.1111\/resp.13034","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T01:08:00Z","timestamp":1490922480000},"page":"662-670","source":"Crossref","is-referenced-by-count":157,"title":["Coal mine dust lung disease in the modern era"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-0615","authenticated-orcid":false,"given":"Jennifer L.","family":"Perret","sequence":"first","affiliation":[{"name":"Lung Health Research Centre (LHRC) The University of Melbourne  Melbourne Victoria Australia"},{"name":"Allergy and Lung Health Unit, Melbourne School of Population and Global Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep 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