{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:24:17Z","timestamp":1779297857609,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01HL102321\u201002"],"award-info":[{"award-number":["5R01HL102321\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HL095491"],"award-info":[{"award-number":["P01HL095491"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL128658"],"award-info":[{"award-number":["R01HL128658"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL102321"],"award-info":[{"award-number":["R01HL102321"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HL10050580"],"award-info":[{"award-number":["P01HL10050580"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL085188"],"award-info":[{"award-number":["R01HL085188"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24HL132105"],"award-info":[{"award-number":["K24HL132105"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21HL121794"],"award-info":[{"award-number":["R21HL121794"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL119201"],"award-info":[{"award-number":["R01HL119201"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL081823"],"award-info":[{"award-number":["R01HL081823"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15SDG25890059"],"award-info":[{"award-number":["15SDG25890059"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1060992"],"award-info":[{"award-number":["1060992"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1053201"],"award-info":[{"award-number":["1053201"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1064163"],"award-info":[{"award-number":["1064163"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1035115"],"award-info":[{"award-number":["1035115"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001222","name":"Menzies Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001465","name":"American Thoracic Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001465","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>\n<jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content>\n<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Upper airway collapsibility predicts the response to several non\u2010continuous positive airway pressure (<jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>) interventions for obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>). Measures of upper airway collapsibility cannot be easily performed in a clinical context; however, a patient's therapeutic <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> requirement may serve as a surrogate measure of collapsibility. The present work aimed to compare the predictive use of <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> level with detailed physiological measures of collapsibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Therapeutic <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> levels and gold\u2010standard pharyngeal collapsibility measures (passive pharyngeal critical closing pressure (P<jats:sub>crit<\/jats:sub>) and ventilation at <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> level of 0\u2009cmH<jats:sub>2<\/jats:sub>O (V<jats:sub>passive<\/jats:sub>)) were retrospectively analysed from a randomized controlled trial (<jats:italic>n<\/jats:italic>\u2009=\u200920) comparing the combination of oxygen and eszopiclone (treatment) versus placebo\/air control. Responders (9\/20) to treatment were defined as those who exhibited a 50% reduction in apnoea\/hypopnoea index (<jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>) plus an <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>&lt;15\u2009events\/h on\u2010therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Responders to treatment had a lower therapeutic <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> requirement compared with non\u2010responders (6.6 (5.4\u20138.1) \u2009<jats:styled-content style=\"fixed-case\">cmH<jats:sub>2<\/jats:sub>O<\/jats:styled-content> vs 8.9 (8.4\u201310.4)\u2009<jats:styled-content style=\"fixed-case\">cmH<jats:sub>2<\/jats:sub>O<\/jats:styled-content>, <jats:italic>P<\/jats:italic>\u2009=\u20090.007), consistent with their reduced collapsibility (lower P<jats:sub>crit<\/jats:sub>, <jats:italic>P<\/jats:italic>\u2009=\u20090.017, higher V<jats:sub>passive<\/jats:sub> <jats:italic>P<\/jats:italic>\u2009=\u20090.025). Therapeutic <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> level provided the highest predictive accuracy for differentiating responders from non\u2010responders (area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>)\u2009=\u20090.86\u2009\u00b1\u20090.9, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.68\u20131.00, <jats:italic>P<\/jats:italic>\u2009=\u20090.007). However, both P<jats:sub>crit<\/jats:sub> (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\u2009=\u20090.83\u2009\u00b1\u20090.11, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.62\u20131.00, <jats:italic>P<\/jats:italic>\u2009=\u20090.017) and V<jats:sub>passive<\/jats:sub> (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\u2009=\u20090.77\u2009\u00b1\u20090.12, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.53\u20131.00, P\u2009=\u20090.44) performed well, and the difference in <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> for these three metrics was not statistically different. A therapeutic <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> level \u22648\u2009cm<jats:styled-content style=\"fixed-case\">H<jats:sub>2<\/jats:sub>O<\/jats:styled-content> provided 78% sensitivity and 82% specificity (positive predictive value\u2009=\u200978%, negative predictive value\u2009=\u200982%) for predicting a response to these therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Therapeutic <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> requirement, as a surrogate measure of pharyngeal collapsibility, predicts the response to non\u2010anatomical therapy (oxygen and eszopiclone) for <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13044","type":"journal-article","created":{"date-parts":[[2017,4,14]],"date-time":"2017-04-14T02:52:41Z","timestamp":1492138361000},"page":"1219-1224","source":"Crossref","is-referenced-by-count":19,"title":["Response to a combination of oxygen and a hypnotic as treatment for obstructive sleep apnoea is predicted by a patient's therapeutic <scp>CPAP<\/scp> requirement"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9041-3655","authenticated-orcid":false,"given":"Shane A.","family":"Landry","sequence":"first","affiliation":[{"name":"Department of Physiology Monash University  Melbourne Victoria Australia"},{"name":"Monash Institute of Cognitive and Clinical Neurosciences Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon A.","family":"Joosten","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Health  Melbourne Victoria Australia"},{"name":"School of Clinical Sciences Monash University  Melbourne Victoria Australia"},{"name":"Monash Partners \u2013 Epworth  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Sands","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology Brigham &amp; Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"White","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology Brigham &amp; Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology Brigham &amp; Women's Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Pulmonary and Critical Care Medicine University of California San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Wellman","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology Brigham &amp; Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garun S.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Health  Melbourne Victoria Australia"},{"name":"School of Clinical Sciences Monash University  Melbourne Victoria Australia"},{"name":"Monash Partners \u2013 Epworth  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9383-1644","authenticated-orcid":false,"given":"Bradley A.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Physiology Monash University  Melbourne Victoria Australia"},{"name":"Monash Institute of Cognitive and Clinical Neurosciences Monash University  Melbourne Victoria Australia"},{"name":"Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology Brigham &amp; Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.6.1300"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0448OC"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00045.2008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.3_Pt_1.494"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201601-0099OC"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.6226"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00282.2006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.110.4.1077"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx056"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.4020"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00121608"},{"key":"e_1_2_7_13_1","volume-title":"International Classification of Sleep Disorders, Revised: Diagnostic and Coding Manual","author":"American Academy of Sleep Medicine.","year":"2001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00747.2012"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00062914"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201404-0718OC"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92140-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2432"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.13044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:36:01Z","timestamp":1696192561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.13044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,13]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/resp.13044"],"URL":"https:\/\/doi.org\/10.1111\/resp.13044","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,13]]}}}