{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T13:21:51Z","timestamp":1781356911161,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006510","name":"Duke University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Peripheral airway involvement in asthma remains poorly understood. We investigated impulse oscillometry (<jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content>) measures of peripheral airway function in a population\u2010based birth cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pre\u2010 and post\u2010bronchodilator spirometry and <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> measures of respiratory resistance and reactance were measured in 915 participants at age 38\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Current asthma was associated with impairments in both spirometry and <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> parameters. These impairments were greater in men and in those with childhood persistent asthma. Spirometry and <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> values for those whose asthma was in remission were not different to non\u2010asthmatic participants. There were significant changes in <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> in both asthmatic and non\u2010asthmatic participants after bronchodilator, but between\u2010group differences persisted. Higher <jats:styled-content style=\"fixed-case\">BMIs<\/jats:styled-content> were associated with impairments in <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> but not spirometry. Cumulative tobacco use was associated with spirometric airflow obstruction in both sexes, whereas cannabis use was associated with impairments in <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> in women. Despite higher lifetime exposure, there were few associations between cannabis and <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Asthma is associated with abnormalities in <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> measures of peripheral airway dysfunction. This association is stronger in men and in those with asthma persisting since childhood. Tobacco and cannabis use are associated with different patterns of spirometry and <jats:styled-content style=\"fixed-case\">IOS<\/jats:styled-content> abnormalities and may affect the bronchial tree at different airway generations with differences in susceptibility between sexes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13045","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T11:35:56Z","timestamp":1491910556000},"page":"1110-1117","source":"Crossref","is-referenced-by-count":23,"title":["Determinants of peripheral airway function in adults with and without asthma"],"prefix":"10.1111","volume":"22","author":[{"given":"Paul D.","family":"Robinson","sequence":"first","affiliation":[{"name":"Woolcock Institute of Medical Research The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Respiratory Medicine The Children's Hospital at Westmead  Sydney New South Wales 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