{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:15:26Z","timestamp":1790392526881,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200066"],"award-info":[{"award-number":["81200066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81541129"],"award-info":[{"award-number":["81541129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>\n<jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content>\n<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Smoking is a leading cause of death in the world. Aberrant brain function has been repeatedly linked to tobacco smoking. However, little is known about insula\u2010based resting\u2010state functional connectivity (<jats:styled-content style=\"fixed-case\">rsFC<\/jats:styled-content>) in non\u2010deprived tobacco\u2010dependent smokers. This study characterized the correlation between insula\u2010based <jats:styled-content style=\"fixed-case\">rsFC<\/jats:styled-content> and tobacco dependence severity in non\u2010deprived smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 37 male smokers and 37 age\u2010matched male non\u2010smokers completed resting\u2010state functional <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>) scans. The insula\u2010based <jats:styled-content style=\"fixed-case\">rsFC<\/jats:styled-content> differences between smokers and controls were investigated and the correlation between insula\u2010based <jats:styled-content style=\"fixed-case\">rsFC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FTND<\/jats:styled-content> (Fagerstr\u00f6m Test for Nicotine Dependence) scores were then assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with controls, smokers showed significantly lower <jats:styled-content style=\"fixed-case\">rsFC<\/jats:styled-content> between orbitofrontal cortex, superior frontal gyrus, temporal lobe and insula. The <jats:styled-content style=\"fixed-case\">rsFC<\/jats:styled-content> between orbitofrontal cortex, temporal lobe, inferior parietal cortex, occipital lobe and insula was positively correlated with <jats:styled-content style=\"fixed-case\">FTND<\/jats:styled-content>. However, the <jats:styled-content style=\"fixed-case\">rsFC<\/jats:styled-content> between anterior cingulate cortex and insula was negatively correlated with <jats:styled-content style=\"fixed-case\">FTND<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest differences in brain functional connectivity between smokers and non\u2010smokers. This study sheds new insights into the neural mechanisms of tobacco dependence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13048","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T16:32:15Z","timestamp":1491409935000},"page":"1118-1124","source":"Crossref","is-referenced-by-count":35,"title":["Effect of smoking on resting\u2010state functional connectivity in smokers: <scp>A<\/scp>n <scp>fMRI<\/scp> study"],"prefix":"10.1111","volume":"22","author":[{"given":"Shuang","family":"Zhou","sequence":"first","affiliation":[{"name":"Medical Research Center, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xiao","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Respiratory Diseases, Center for Respiratory Diseases China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Tobacco Medicine and Tobacco Cessation Center China\u2010Japan Friendship Hospital  Beijing China"},{"name":"WHO Collaborating Centre for Tobacco Cessation and Respiratory Diseases Prevention China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang\u2010Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Respiratory Diseases, Center for Respiratory Diseases China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Tobacco Medicine and Tobacco Cessation Center China\u2010Japan Friendship Hospital  Beijing China"},{"name":"WHO Collaborating Centre for Tobacco Cessation and Respiratory Diseases Prevention China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Yan","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Respiration Affiliated Hospital of Wei\u2010Fang Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Shu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiration Hainan Branch of the General Hospital of People's Liberation Army  Sanya China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Respiratory Diseases, Center for Respiratory Diseases China\u2010Japan Friendship Hospital  Beijing China"},{"name":"WHO Collaborating Centre for Tobacco Cessation and Respiratory Diseases Prevention China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Department of Pulmonary and Critical Care Medicine China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Department of Respiratory Medicine Capital Medical University  Beijing China"},{"name":"Capital Medical University Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization. WHO report on the global tobacco epidemic. 2008\u2010The MPOWER package. Geneva: WHO 2008"},{"key":"e_1_2_7_3_1","unstructured":"Chinese Center for Disease Control and Prevention. 2015 China adult tobacco survey report. Beijing 2015."},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","unstructured":"ChenZ PetoR ZhouM IonaA SmithM YangL GuoY ChenY Bian Z Lancaster Get al.;China Kadoorie Biobank (CKB) Collaborative Group. Contrasting male and female trends in tobacco\u2010attributed mortality in China: evidence from successive nationwide prospective cohort studies.Lancet2015;386:1447\u201356.","DOI":"10.1016\/S0140-6736(15)00340-2"},{"key":"e_1_2_7_5_1","unstructured":"BeagleholeR BonitaR HortonR AdamsC AlleyneG AsariaP BaughV BekedamH BilloN CasswellSet al.;Lancet NCD Action Group;NCD Alliance. Priority actions for the non\u2010communicable disease crisis.Lancet2011;377:1438\u201347."},{"key":"e_1_2_7_6_1","volume-title":"The ICD\u201010 Classification of Mental and Behavioral Disorders: Clinical Descriptions and Diagnostic Guidelines","author":"World Health Organization","year":"1992"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.56"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.09.021"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.02.020"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059331"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-016-4262-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23153"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0268-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2555"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0248-y"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.074"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135926"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.01.023"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.05.021"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2010.11.016"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01879.x"},{"key":"e_1_2_7_24_1","first-page":"13","article-title":"DPARSF: a MATLAB toolbox for \"Pipeline\" data analysis of resting\u2010state fMRI","volume":"4","author":"Yan C","year":"2010","journal-title":"Front. Syst. Neurosci."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025031"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(02)00199-X"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012120"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12415"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/9780262016438.001.0001"},{"key":"e_1_2_7_30_1","first-page":"22","article-title":"Neural correlates of the development of cognitive control","volume":"55","author":"Bunge SA","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.05.031"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.134"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.12.1162"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.62"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi005"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht154"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12262"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.2"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106138"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300780"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.103"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800005105"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4465-11.2011"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.13048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:36:10Z","timestamp":1696192570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.13048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,4]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/resp.13048"],"URL":"https:\/\/doi.org\/10.1111\/resp.13048","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,4]]}}}