{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:46:34Z","timestamp":1789980394885,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007772","name":"Agir pour les Maladies Chroniques","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"\nABSTRACT<\/jats:styled-content>\n<\/jats:title>Background and objective<\/jats:title>The prevalence of obesity hypoventilation syndrome (OHS<\/jats:styled-content>) in the unselected obese is unknown. Our objectives were: (i) to determine the prevalence of OHS<\/jats:styled-content> in ambulatory obese patients not previously referred to a pulmonologist for suspicion of sleep breathing disorders and (ii) to assess whether venous bicarbonate concentration [HCO3<\/jats:sub>\n<\/jats:styled-content>\n\u2212<\/jats:sup>\nv<\/jats:sub>] can be used to detect OHS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this prospective multicentric study, we measured [HCO3<\/jats:sub>\n<\/jats:styled-content>\n\u2212<\/jats:sup>\nv<\/jats:sub>] in consenting obese patients attending pathology analysis laboratories. Patients with [HCO3<\/jats:sub>\n<\/jats:styled-content>\n\u2212<\/jats:sup>\nv<\/jats:sub>]\u2009\u2265\u200927\u2009mmol\/L were referred to a pulmonologist for comprehensive sleep and respiratory evaluations. Those with [HCO3<\/jats:sub>\n<\/jats:styled-content>\n\u2212<\/jats:sup>\nv<\/jats:sub>]\u2009<\u200927\u2009mmol\/L were randomized to either referral to a pulmonologist or ended the study.<\/jats:p><\/jats:sec>Results<\/jats:title>For the 1004 screened patients, the [HCO3<\/jats:sub>\n<\/jats:styled-content>\n\u2212<\/jats:sup>\nv<\/jats:sub>] was \u226527 mmol\/L in 24.6% and <27 mmol\/L in 45.9%. A total of 29.5% who had previously consulted a pulmonologist were excluded. A population of 241 obese patients underwent sleep and respiratory assessments. The prevalence of OHS<\/jats:styled-content> in this population was 1.10 (95% CI<\/jats:styled-content>\u2009=\u20090.51; 2.27). In multivariate analysis, PaCO2<\/jats:sub>\n<\/jats:styled-content>, forced expiratory volume in 1\u2009s (FEV1<\/jats:sub>\n<\/jats:styled-content>), apnoea\u2013hypopnoea index (AHI<\/jats:styled-content>), BMI<\/jats:styled-content>, use of \u22653 anti\u2010hypertensive drugs, anti\u2010diabetics, proton pump inhibitors and\/or paracetamol were related to raised [HCO3<\/jats:sub>\n<\/jats:styled-content>\n\u2212<\/jats:sup>\nv<\/jats:sub>].<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The prevalence of OHS<\/jats:styled-content> in our obese population was lower than previous estimations based on hospitalized patients or clinical cohorts with sleep breathing disorders. Apart from hypercapnia, increased [HCO3<\/jats:sub>\n<\/jats:styled-content>\n\u2212<\/jats:sup>\nv<\/jats:sub>] may also reflect multimorbidity and polypharmacy, which should be taken into account when using [HCO3<\/jats:sub>\n<\/jats:styled-content>\n\u2212<\/jats:sup>\nv<\/jats:sub>] to screen for OHS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13051","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T11:54:38Z","timestamp":1491911678000},"page":"1190-1198","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence of obesity hypoventilation syndrome in ambulatory obese patients attending pathology laboratories"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4140-6210","authenticated-orcid":false,"given":"Jean\u2010Christian","family":"Borel","sequence":"first","affiliation":[{"name":"HP2 Laboratory, INSERM U1042, Grenoble Alpes University Grenoble France"},{"name":"AGIR \u00e0 dom. 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