{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:04:31Z","timestamp":1789970671430,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["DLD\/14526278"],"award-info":[{"award-number":["DLD\/14526278"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["PAP\/14526182"],"award-info":[{"award-number":["PAP\/14526182"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"\nABSTRACT<\/jats:styled-content>\n<\/jats:title>Background and objective<\/jats:title>Acute exacerbation (AE<\/jats:styled-content>) of idiopathic pulmonary fibrosis (IPF<\/jats:styled-content>) (AE\u2010IPF<\/jats:styled-content>) is a poor prognostic disorder. AE<\/jats:styled-content> is also reported to occur in other idiopathic interstitial pneumonias (IIPs<\/jats:styled-content>). There are limited data available regarding the effectiveness of treatment for AE\u2010IIPs<\/jats:styled-content>. The objective of this study was to clarify the prognostic impact of the initial dose of prednisolone (PSL<\/jats:styled-content>) for treating AE\u2010IIPs<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eighty\u2010five patients with AE\u2010IIPs<\/jats:styled-content>, diagnosed according to the criteria of the Japanese Respiratory Society, were enrolled in this study (IPF<\/jats:styled-content>\/non\u2010IPF<\/jats:styled-content>: 63\/22 patients) from 2004 to 2013. We performed multivariate Cox proportional hazard regression analysis to identify poor prognostic factors. HRCT<\/jats:styled-content> patterns at the onset of AE\u2010IIPs<\/jats:styled-content> were classified as diffuse or non\u2010diffuse. We evaluated the prognostic significance of the initial dose of PSL<\/jats:styled-content> by adjusting for other prognostic factors.<\/jats:p><\/jats:sec>Results<\/jats:title>Median survival time (MST<\/jats:styled-content>) after AE\u2010IIPs<\/jats:styled-content> diagnosis was 49\u2009days. MST<\/jats:styled-content> of AE\u2010IPF<\/jats:styled-content> and AE<\/jats:styled-content>\u2010non\u2010IPF<\/jats:styled-content> was 39 and 49\u2009days, respectively. A diffuse HRCT<\/jats:styled-content> pattern, lower serum IgG and higher serum surfactant protein\u2010D at AE<\/jats:styled-content> diagnosis, long\u2010term oxygen therapy (LTOT<\/jats:styled-content>) before AE<\/jats:styled-content> and positive pressure ventilation (PPV<\/jats:styled-content>) use for AE<\/jats:styled-content> were significant poor prognostic factors for all patients, as were LTOT<\/jats:styled-content> before AE<\/jats:styled-content> and lower serum IgG<\/jats:styled-content> for no\u2010PPV<\/jats:styled-content> patients. High\u2010dose PSL<\/jats:styled-content>\u2009\u2265\u20090.6\u2009mg\/kg was a significant prognostic factor for no\u2010PPV<\/jats:styled-content> patients after adjusting for other prognostic factors.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We concluded that a dose of PSL<\/jats:styled-content>\u2009\u2265\u20090.6\u2009mg\/kg after i.v. high\u2010dose methylprednisolone therapy should be recommended for the treatment of AE\u2010IIPs<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13065","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T04:46:50Z","timestamp":1494910010000},"page":"1363-1370","source":"Crossref","is-referenced-by-count":40,"title":["High\u2010dose prednisolone after intravenous methylprednisolone improves prognosis of acute exacerbation in idiopathic interstitial pneumonias"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2222-0683","authenticated-orcid":false,"given":"Toru","family":"Arai","sequence":"first","affiliation":[{"name":"Clinical Research Center National Hospital Organization, Kinki\u2010Chuo Chest Medical Center Sakai City Japan"},{"name":"Department of Internal Medicine National Hospital Organization, Kinki\u2010Chuo Chest Medical Center Sakai City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunobu","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Hospital Organization, Kinki\u2010Chuo Chest Medical Center Sakai City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikatoshi","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital Organization, Kinki\u2010Chuo Chest Medical Center Sakai City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-874X","authenticated-orcid":false,"given":"Yasushi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Hospital Organization, Kinki\u2010Chuo Chest Medical Center Sakai City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayoko","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Hospital Organization, Kinki\u2010Chuo Chest Medical Center Sakai City Japan"},{"name":"Department of Radiology National Hospital Organization, Kinki\u2010Chuo Chest Medical Center Sakai City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Okuma","sequence":"additional","affiliation":[{"name":"Department of Radiology Osaka City University Graduate School of Medicine Osaka City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Akira","sequence":"additional","affiliation":[{"name":"Department of Radiology National Hospital Organization, Kinki\u2010Chuo Chest Medical Center Sakai City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kitaichi","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization, Minami Wakayama Medical Center Tanabe City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Hospital Organization, Kinki\u2010Chuo Chest Medical Center Sakai City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital Organization, Kinki\u2010Chuo Chest Medical Center Sakai City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"RaghuG CollardHR EganJJ MartinezFJ BehrJ BrownKK ColbyTV CordierJF FlahertyKR LaskyJAet al.;on behalf of the ATS\/ERS\/JRS\/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence\u2010based guidelines for diagnosis and management.Am. J. Respir. Crit. Care Med.2011;183:788\u2013824."},{"key":"e_1_2_7_3_1","unstructured":"CollardHR MooreBB FlahertyKR BrownKK KanerRJ KingTEJr LaskyJA LoydJE NothI OlmanMAet al.;with the Idiopathic Pulmonary Fibrosis Clinical Research Network Investigators. Acute exacerbation of idiopathic pulmonary fibrosis.Am. J. Respir. Crit. Care Med.2007;176:636\u201343."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.6.1808"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0323"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.2359"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4327"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00127311"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355485"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00159709"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.6965"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5780"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.10019"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.6018"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2008.01290.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000287232"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.08.032"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330325"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","unstructured":"TaniguchiH EbinaY KondohT OguraT AzumaA SugaM TaguchiY TakahashiH NakataK SatoAet al.;Pirfenidone Clinical Study Group. Pirfenidone in idiopathic pulmonary fibrosis. A phase III clinical trail in Japan.Eur. Respir. J.2010;35:821\u20139.","DOI":"10.1183\/09031936.00005209"},{"key":"e_1_2_7_20_1","first-page":"113","article-title":"Polymyxin\u2010B hemoperfusion for acute exacerbation of idiopathic pulmonary fibrosis: serum IL\u20107 as a prognostic marker","volume":"28","author":"Tachibana K","year":"2011","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.168.1.8976924"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200709-1365OC"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0801CI"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","unstructured":"InoueY TrapnellBC TazawaR AraiT TakadaT HizawaN KasaharaY TatsumiK HojoM IchiwataTet al.;Japanese Center of the Rare Lung Diseases Consortium. Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan.Am. J. Respir. Crit. Care Med.2008;177:752\u201362.","DOI":"10.1164\/rccm.200708-1271OC"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213341.70852.9d"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.2.159"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2100"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2014.08.014"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-116"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0004-4"},{"key":"e_1_2_7_31_1","first-page":"343","article-title":"A pilot study: a combined therapy using polymyxin\u2010B hemoperfusion and extracorporeal membrane oxygenation for acute exacerbation of interstitial pneumonia","volume":"31","author":"Ital J","year":"2015","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329891"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90637.2008"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00108111"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32556-5"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2012.02.001"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-013-9530-0"},{"key":"e_1_2_7_38_1","article-title":"Prognostic evaluation by oxygenation with positive end\u2010expiratory pressure in acute exacerbation of idiopathic pulmonary fibrosis: a retrospective cohort study","author":"Suzuki A","year":"2016","journal-title":"Clin. Respir. J."}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.13065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T15:52:30Z","timestamp":1696175550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.13065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,15]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/resp.13065"],"URL":"https:\/\/doi.org\/10.1111\/resp.13065","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,15]]}}}