{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:29:59Z","timestamp":1761766199810,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>\n<jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content>\n<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Lobar and temporal histological variability in chronic bird\u2010related hypersensitivity pneumonitis (<jats:styled-content style=\"fixed-case\">BRHP<\/jats:styled-content>) has not been clearly elucidated. This study was designed to evaluate the spatio\u2010temporal histopathological variability in chronic <jats:styled-content style=\"fixed-case\">BRHP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010two patients with chronic <jats:styled-content style=\"fixed-case\">BRHP<\/jats:styled-content> who underwent a surgical lung biopsy (<jats:styled-content style=\"fixed-case\">SLB<\/jats:styled-content>) between 1992 and 2008 were evaluated. The histopathological characteristics of the lung biopsy specimens were classified by the 2002 American Thoracic Society\/European Respiratory Society (<jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ERS<\/jats:styled-content>) consensus classification of idiopathic interstitial pneumonias (<jats:styled-content style=\"fixed-case\">IIPs<\/jats:styled-content>). Autopsy specimens from seven patients were also evaluated to examine the serial changes from <jats:styled-content style=\"fixed-case\">SLB<\/jats:styled-content> to autopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a study of lobar histological variability based on the findings of <jats:styled-content style=\"fixed-case\">SLB<\/jats:styled-content>, 7 patients were diagnosed with cellular nonspecific interstitial pneumonia (<jats:styled-content style=\"fixed-case\">NSIP<\/jats:styled-content>) pattern, 16 with fibrotic <jats:styled-content style=\"fixed-case\">NSIP<\/jats:styled-content> pattern, 20 with fibrotic <jats:styled-content style=\"fixed-case\">NSIP<\/jats:styled-content> pattern and usual interstitial pneumonia (<jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content>) (discordant <jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content>) pattern and 9 with <jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content> (concordant <jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content>) pattern. In a study of sequential changes, specimens of <jats:styled-content style=\"fixed-case\">SLBs<\/jats:styled-content> with fibrotic <jats:styled-content style=\"fixed-case\">NSIP<\/jats:styled-content> pattern changed to a bronchiolocentric interstitial pneumonia (<jats:styled-content style=\"fixed-case\">BIP<\/jats:styled-content>) pattern or <jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content> pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Interlobar and intralobar histological variability is present in chronic <jats:styled-content style=\"fixed-case\">BRHP<\/jats:styled-content>. In several patients with chronic <jats:styled-content style=\"fixed-case\">BRHP<\/jats:styled-content>, a fibrotic <jats:styled-content style=\"fixed-case\">NSIP<\/jats:styled-content> pattern may be an early lesion that progresses to a <jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content> pattern.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13070","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T10:28:41Z","timestamp":1495016921000},"page":"1350-1356","source":"Crossref","is-referenced-by-count":7,"title":["Histological variability and consequences in chronic bird\u2010related hypersensitivity pneumonitis"],"prefix":"10.1111","volume":"22","author":[{"given":"Junichi","family":"Ochi","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Ohtani","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamiko","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Pathology Japan Red Cross Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Akashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Medical and Dental University  Tokyo 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