{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:07:57Z","timestamp":1787800077043,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL130307"],"award-info":[{"award-number":["R01HL130307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"\n ABSTRACT<\/jats:styled-content>\n <\/jats:title>\n \n Background and objective<\/jats:title>\n \n A dilated pulmonary artery (\n PA<\/jats:styled-content>\n ) is a common finding in patients with pulmonary arterial hypertension (\n PAH<\/jats:styled-content>\n ). Little is known on the variations in\n PA<\/jats:styled-content>\n size over time and whether these changes track with disease severity and\/or predict long\u2010term survival.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We included patients with\n PAH<\/jats:styled-content>\n who had at least two computed tomography (\n CT<\/jats:styled-content>\n ) scans of the chest done on different visits. Both scans matched the use of i.v. contrast.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Pairs of\n CT<\/jats:styled-content>\n scans were compared in 113\n PAH<\/jats:styled-content>\n patients. During a median (interquartile range (\n IQR<\/jats:styled-content>\n )) time difference between scans of 8 (IQR: 3.5\u201320.0) months, we noted an increase in main\n PA<\/jats:styled-content>\n diameter of 0.5\u2009\u00b1\u20091.8\u2009mm (mean\u2009\u00b1\u2009\n SD<\/jats:styled-content>\n ) (\n P<\/jats:italic>\n \u2009=\u20090.008). When\n CT<\/jats:styled-content>\n scans were performed >12\u2009months apart (\n n<\/jats:italic>\n \u2009=\u200947), the main\n PA<\/jats:styled-content>\n diameter increased or decreased by >1\u2009mm in 40% and 13% of the patients, respectively. An increase in main\n PA<\/jats:styled-content>\n diameter was associated with lower\n PA<\/jats:styled-content>\n compliance, higher right ventricular (\n RV<\/jats:styled-content>\n ) systolic pressure, worse\n RV<\/jats:styled-content>\n function and a decline in 6\u2010min walk distance. During a median (\n IQR<\/jats:styled-content>\n ) follow\u2010up of 33 (IQR: 4.5\u201347) months, 53 (46.9%) patients died. The change in\n PA<\/jats:styled-content>\n diameter was a significant predictor of mortality (hazard ratio (\n HR<\/jats:styled-content>\n ) per mm increase: 1.33 (95%\n CI<\/jats:styled-content>\n : 1.11\u20131.61),\n P<\/jats:italic>\n \u2009=\u20090.002) when adjusted for difference in time and slice thickness between\n CT<\/jats:styled-content>\n scans, age, gender,\n PAH<\/jats:styled-content>\n aetiology and pulmonary vascular resistance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In\n PAH<\/jats:styled-content>\n patients, an increase in\n CT<\/jats:styled-content>\n \u2010derived main\n PA<\/jats:styled-content>\n diameter over time is associated with progression in pulmonary pressures,\n RV<\/jats:styled-content>\n dysfunction, a decline in functional capacity and higher mortality.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.13073","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T06:26:41Z","timestamp":1495002401000},"page":"1649-1655","source":"Crossref","is-referenced-by-count":30,"title":["Changes in main pulmonary artery diameter during follow\u2010up have prognostic implications in pulmonary arterial hypertension"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2321-9545","authenticated-orcid":false,"given":"Adriano R.","family":"Tonelli","sequence":"first","affiliation":[{"name":"Department of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Imaging Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laith","family":"Alkukhun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medicine Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Imaging Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed A.","family":"Dweik","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201209-1640OC"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201406-253PP"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-199910000-00007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2016.1157442"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12529"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.029"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.032"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.83a.14186"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0b013e318271c2eb"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.2.9805075"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0363"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.968610"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00240678"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2794"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.13073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T13:26:53Z","timestamp":1695994013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.13073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,17]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/resp.13073"],"URL":"https:\/\/doi.org\/10.1111\/resp.13073","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,17]]}}}