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Nevertheless, despite antibiotics, the burden of disease in pneumonia, bronchiectasis, cystic fibrosis, <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> and rare respiratory infections remains exceptionally high. There is an urgent need for translational studies to develop new treatments or new biomarkers to improve outcomes in these conditions. The \u2018translational gaps\u2019 between bench science and clinical practice are particularly challenging in respiratory infections. This is partly due to the poor representativeness of animal models of infection to human disease, and a long\u2010term lack of investment into pulmonary infection research.<\/jats:p><jats:p>The revolution in genomics and other omics technologies, however, is beginning to unlock clinically important information about the host response to infection, the behaviour of bacterial communities and the development of new antibiotics. It is not possible to review the extensive progress made in the last decade into the pathophysiology of the different respiratory infections and so here, we focus on major technologies that are now changing respiratory infection research, specifically bacterial whole\u2010genome sequencing, the microbiota, personalized medicine with omics technologies, new antibiotic development and host inflammatory cell biology.<\/jats:p>","DOI":"10.1111\/resp.13106","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T11:22:34Z","timestamp":1498648954000},"page":"1062-1072","source":"Crossref","is-referenced-by-count":8,"title":["The past decade in bench research into pulmonary infectious diseases: <scp>W<\/scp>hat do clinicians need to know?"],"prefix":"10.1111","volume":"22","author":[{"given":"Simon","family":"Finch","sequence":"first","affiliation":[{"name":"Scottish Centre for Respiratory Research University of Dundee, Ninewells Hospital and Medical School  Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly R.","family":"Keir","sequence":"additional","affiliation":[{"name":"Scottish Centre for Respiratory Research University of Dundee, Ninewells Hospital and Medical School  Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison J.","family":"Dicker","sequence":"additional","affiliation":[{"name":"Scottish Centre for Respiratory Research University of Dundee, Ninewells Hospital and Medical School  Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-7868","authenticated-orcid":false,"given":"James D.","family":"Chalmers","sequence":"additional","affiliation":[{"name":"Scottish Centre for Respiratory Research University of Dundee, Ninewells Hospital and Medical School  Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Obama administration releases national action plan to combat antibiotic resistant bacteria. 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