{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:27:30Z","timestamp":1792412850781,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1035115"],"award-info":[{"award-number":["1035115"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1064163"],"award-info":[{"award-number":["1064163"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15SDG25890059"],"award-info":[{"award-number":["15SDG25890059"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL128658"],"award-info":[{"award-number":["R01HL128658"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R01HL102321"],"award-info":[{"award-number":["2R01HL102321"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HL10050580"],"award-info":[{"award-number":["P01HL10050580"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title><jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content><\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>) is typically worse in the supine versus lateral sleeping position. One potential factor driving this observation is a decrease in lung volume in the supine position which is expected by theory to increase a key <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> pathogenic factor: dynamic ventilatory control instability (i.e. loop gain). We aimed to quantify dynamic loop gain in <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> patients in the lateral and supine positions, and to explore the relationship between change in dynamic loop gain and change in lung volume with position.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 20 patients enrolled in previous studies on the effect of body position on <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> pathogenesis were retrospectively analysed. Dynamic loop gain was calculated from routinely collected polysomnographic signals using a previously validated mathematical model. Lung volumes were measured in the awake state with a nitrogen washout technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dynamic loop gain was significantly higher in the supine than in the lateral position (0.77\u2009\u00b1\u20090.15 vs 0.68\u2009\u00b1\u20090.14, <jats:italic>P<\/jats:italic>\u2009=\u20090.012). Supine functional residual capacity (<jats:styled-content style=\"fixed-case\">FRC<\/jats:styled-content>) was significantly lower than lateral <jats:styled-content style=\"fixed-case\">FRC<\/jats:styled-content> (81.0\u2009\u00b1\u200915.4% vs 87.3\u2009\u00b1\u200918.4% of the seated <jats:styled-content style=\"fixed-case\">FRC<\/jats:styled-content>, <jats:italic>P<\/jats:italic>\u2009=\u20090.021). The reduced <jats:styled-content style=\"fixed-case\">FRC<\/jats:styled-content> we observed on moving to the supine position was predicted by theory to increase loop gain by 10.2 (0.6, 17.1)%, a value similar to the observed increase of 8.4 (\u22121.5, 31.0)%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dynamic loop gain increased by a small but statistically significant amount when moving from the lateral to supine position and this may, in part, contribute to the worsening of <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> in the supine sleeping position.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13108","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T01:32:43Z","timestamp":1500600763000},"page":"1662-1669","source":"Crossref","is-referenced-by-count":53,"title":["Dynamic loop gain increases upon adopting the supine body position during sleep in patients with obstructive sleep apnoea"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7909-8025","authenticated-orcid":false,"given":"Simon A.","family":"Joosten","sequence":"first","affiliation":[{"name":"Monash Lung and Sleep Monash Medical Centre  Clayton VIC Australia"},{"name":"School of Clinical Sciences Monash University  Melbourne VIC Australia"},{"name":"Monash Partners \u2013 Epworth Sleep Centre  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9041-3655","authenticated-orcid":false,"given":"Shane A.","family":"Landry","sequence":"additional","affiliation":[{"name":"Sleep and Circadian Medicine Laboratory, Department of Physiology Monash University  Melbourne VIC Australia"},{"name":"School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences Monash University  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Sands","sequence":"additional","affiliation":[{"name":"Department of Allergy, Immunology and Respiratory Medicine and Central Clinical School The Alfred and Monash University  Melbourne VIC Australia"},{"name":"Division of Sleep and Circadian Disorders, Department of Medicine Brigham and Women's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip I.","family":"Terrill","sequence":"additional","affiliation":[{"name":"School of Information Technology and Electrical Engineering The University of Queensland  Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwayne","family":"Mann","sequence":"additional","affiliation":[{"name":"School of Information Technology and Electrical Engineering The University of Queensland  Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Andara","sequence":"additional","affiliation":[{"name":"Monash Partners \u2013 Epworth Sleep Centre  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Skuza","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Medical Centre  Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Turton","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Medical Centre  Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Berger","sequence":"additional","affiliation":[{"name":"Sleep and Circadian Medicine Laboratory, Department of Physiology Monash University  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garun 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