{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:09:13Z","timestamp":1791212953053,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institutional (Istituti Clinici Scientifici Maugeri)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"\nABSTRACT<\/jats:styled-content><\/jats:title>Background and objective<\/jats:title>The role of non\u2010invasive ventilation (NIV<\/jats:styled-content>) during exercise training (ET<\/jats:styled-content>) in patients with chronic respiratory failure (CRF<\/jats:styled-content>) is still unclear. The aim of this study was to test whether NIV<\/jats:styled-content> during ET<\/jats:styled-content> had an additional effect in increasing the 6\u2010min walking distance (6MWD<\/jats:styled-content>) and cycle endurance time compared with ET<\/jats:styled-content> alone.<\/jats:p><\/jats:sec>Methods<\/jats:title>All patients underwent 20 sessions of cycle training over 3\u2009weeks and were randomly assigned to ET<\/jats:styled-content> with NIV<\/jats:styled-content> or ET<\/jats:styled-content> alone. Outcome measures were 6MWD<\/jats:styled-content> (primary outcome), incremental and endurance cycle ergometer exercise time, respiratory muscle function, quality of life by the Maugeri Respiratory Failure questionnaire (MRF<\/jats:styled-content>\u201028), dyspnoea (Medical Research Council scale) and leg fatigue at rest.<\/jats:p><\/jats:sec>Results<\/jats:title>Forty\u2010two patients completed the study. Following training, no significant difference in 6MWD<\/jats:styled-content> changes were found between groups. Improvement in endurance time was significantly greater in the NIV<\/jats:styled-content> group compared with the non\u2010NIV<\/jats:styled-content> training group (754\u2009\u00b1\u2009973 vs 51\u2009\u00b1\u2009406\u2009s, P<\/jats:italic>\u2009=\u20090.0271); dyspnoea improved in both groups, while respiratory muscle function and leg fatigue improved only in the NIV ET<\/jats:styled-content> group. MRF<\/jats:styled-content>\u201028 improved only in the group training without NIV<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In CRF<\/jats:styled-content> patients on long\u2010term NIV<\/jats:styled-content> and long\u2010term oxygen therapy (LTOT<\/jats:styled-content>), the addition of NIV<\/jats:styled-content> to ET<\/jats:styled-content> sessions resulted in an improvement in endurance time, but not in 6MWD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13181","type":"journal-article","created":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T01:46:57Z","timestamp":1506131217000},"page":"182-189","source":"Crossref","is-referenced-by-count":33,"title":["Non\u2010invasive ventilation during cycle exercise training in patients with chronic respiratory failure on long\u2010term ventilatory support: A<\/scp> randomized controlled trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-7915","authenticated-orcid":false,"given":"Michele","family":"Vitacca","sequence":"first","affiliation":[{"name":"Respiratory Rehabilitation Division Istituti Clinici Scientifici Maugeri IRCCS Lumezzane Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7951-2065","authenticated-orcid":false,"given":"Dicle","family":"Kaymaz","sequence":"additional","affiliation":[{"name":"Pulmonary Rehabilitation and Home Care Center Ataturk Chest Diseases and Chest Surgery Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6939-1439","authenticated-orcid":false,"given":"Barbara","family":"Lanini","sequence":"additional","affiliation":[{"name":"Respiratory Unit Fondazione Don Gnocchi IRCCS Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-2809","authenticated-orcid":false,"given":"Guido","family":"Vagheggini","sequence":"additional","affiliation":[{"name":"Respiratory Unit Auxilium Vitae Volterra Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8169-4689","authenticated-orcid":false,"given":"P\u0131nar","family":"Erg\u00fcn","sequence":"additional","affiliation":[{"name":"Pulmonary Rehabilitation and Home Care Center Ataturk Chest Diseases and Chest Surgery Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4608-2059","authenticated-orcid":false,"given":"Francesco","family":"Gigliotti","sequence":"additional","affiliation":[{"name":"Respiratory Unit Fondazione Don Gnocchi IRCCS Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-1393","authenticated-orcid":false,"given":"Nicolino","family":"Ambrosino","sequence":"additional","affiliation":[{"name":"Pulmonary and Respiratory Medicine Department Medical Faculty Sebelas Maret University Solo Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3982-2098","authenticated-orcid":false,"given":"Mara","family":"Paneroni","sequence":"additional","affiliation":[{"name":"Respiratory Rehabilitation Division Istituti Clinici Scientifici Maugeri IRCCS Lumezzane Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"SpruitMA SinghSJ GarveyC ZuWallackR NiciL RochesterC HillK HollandAE LareauSC ManWDet al.;ATS\/ERS Task Force on Pulmonary Rehabilitation. 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