{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:19:09Z","timestamp":1781756349702,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Pleuroscopy is the test of choice for patients with suspected malignant pleural effusion and negative cytology. Biopsies negative for malignancy are frequently attributed to non\u2010specific pleuritis, which poses a dilemma in patients with a known active malignancy, raising concern for a false\u2010negative result. Our primary objective was to determine the outcomes of patients with active malignancy who had a non\u2010malignant diagnosis on pleuroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of all pleuroscopy cases from January 2005 to January 2015 at our institution was conducted. Biopsies were categorized by histopathology as malignant, eosinophilic or non\u2010specific pleuritis. Malignant histopathology was considered a true positive. Eosinophilic or non\u2010specific pleuritis was categorized as malignant, if malignancy was later identified during follow\u2010up, or chemotherapy induced, possible radiation induced, other paramalignant, other benign or idiopathic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 199 pleuroscopy cases reviewed, 172 (86%) had a history of active malignancy. On histopathology, 73 (42%) had malignancy, 9 (5%) had eosinophilic pleuritis and 90 (52%) had non\u2010specific pleuritis. Three patients with non\u2010specific pleuritis were diagnosed with malignancy at follow\u2010up. Pleuritis in 24 patients was chemotherapy induced, 27 were possibly radiation induced, 11 were other paramalignant and 3 were other benign. Idiopathic pleuritis was diagnosed in 31 patients. Patients were monitored for a mean of 23\u2009\u00b1\u200911\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of malignant pleural disease was lower than expected for our patient population. Patients with no malignancy on histopathology were most likely to have non\u2010specific pleuritis, a cause for which was identified in a majority of patients after clinical review.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13187","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T14:12:35Z","timestamp":1507817555000},"page":"213-219","source":"Crossref","is-referenced-by-count":25,"title":["Non\u2010specific pleuritis in patients with active malignancy"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2590-882X","authenticated-orcid":false,"given":"Erik","family":"Vakil","sequence":"first","affiliation":[{"name":"McGovern Medical School University of Texas Health Sciences Center at Houston  Houston TX USA"},{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ost","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena R.","family":"Vial","sequence":"additional","affiliation":[{"name":"Interventional Pulmonology Unit, Santiago Alemana Clinic Desarrollo University  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Cytology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona G.","family":"Sarkiss","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo C.","family":"Morice","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto F.","family":"Casal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgie A.","family":"Eapen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-4268","authenticated-orcid":false,"given":"Horiana B.","family":"Grosu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.58.suppl_2.ii29"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000060"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000081755"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991115)86:10<1992::AID-CNCR16>3.0.CO;2-M"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.01.057"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.5.1677"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90100-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083404"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3283470293"},{"key":"e_1_2_6_11_1","volume-title":"Pleural Diseases","author":"Light R","year":"2013"},{"key":"e_1_2_6_12_1","unstructured":"MoschosC KalomenidisI. 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