{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:52:46Z","timestamp":1769575966783,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Cryptogenic organizing pneumonia (COP) is corticosteroid responsive but residual computed tomography (CT) chest changes are often noted. The present study examined clinical and HRCT features of COP in which there was incomplete resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 93 patients with histopathologically confirmed COP and serial HRCT imaging. Clinical features were assessed, and serial CT images were analysed. Uni\u2010 and multivariate analyses were performed to determine clinical or imaging factors related to incomplete resolution on CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete resolution on CT imaging was seen in 21\/93 patients (23%) and residual abnormalities were seen in 72\/93 patients (77%). In univariate analysis, total lesion (<jats:italic>P<\/jats:italic>\u2009=\u20090.036), degree of consolidation (<jats:italic>P<\/jats:italic>\u2009=\u20090.011), treatment duration (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and single\u2010breath carbon monoxide diffusing capacity of lung (<jats:italic>P<\/jats:italic>\u2009=\u20090.021) were significantly associated with residual imaging abnormalities. In multivariate analysis, extent of consolidation (<jats:italic>P<\/jats:italic>\u2009=\u20090.018; odds ratio (OR)\u2009=\u200914.92) and treatment duration (<jats:italic>P<\/jats:italic>\u2009=\u20090.011; OR\u2009=\u20091.32) remained as significant factors linked to residual abnormalities. CT images in unresolved COP were akin to fibrotic non\u2010specific interstitial pneumonia (fNSIP) in 53\/72 (74%) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical, radiological and lung diffusion measurements were related to incomplete resolution on CT after COP. Imaging abnormalities on CT chest generally resembled fNSIP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13188","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:47:06Z","timestamp":1506613626000},"page":"325-330","source":"Crossref","is-referenced-by-count":27,"title":["Serial chest CT in cryptogenic organizing pneumonia: Evolutional changes and prognostic determinants"],"prefix":"10.1111","volume":"23","author":[{"given":"Man P.","family":"Chung","sequence":"first","affiliation":[{"name":"Division of Respiratory and Critical Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo D.","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Radiology and Center for Imaging Science Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3660-5728","authenticated-orcid":false,"given":"Kyung S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Center for Imaging Science Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joungho","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai S.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology Soonchunhyang University Bucheon Hospital, Soonchunhyang University School of Medicine  Bucheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Radiology Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min J.","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Radiology and Center for Imaging Science Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology and Center for Imaging Science Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"e_1_2_6_3_1","first-page":"382","article-title":"Cryptogenic organizing pneumonitis","volume":"52","author":"Davison AG","year":"1983","journal-title":"Q. J. Med."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.170.2.9456931"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.3.8109493"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.162.1.3786754"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.154.5.2108572"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.6.8004328"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2015.78.3.190"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.2.9909015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.09.015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3664"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200303000-00027"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1685OC"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3940"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.05.001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.6.1599"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.13188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:02:05Z","timestamp":1695481325000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.13188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,27]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/resp.13188"],"URL":"https:\/\/doi.org\/10.1111\/resp.13188","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,27]]}}}