{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:52:48Z","timestamp":1784829168618,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Japanese Ministry of Health, Labour, and Welfare","award":["17933141"],"award-info":[{"award-number":["17933141"]}]},{"name":"Japanese Ministry of Health, Labour, and Welfare","award":["17930161"],"award-info":[{"award-number":["17930161"]}]},{"name":"Japanese Ministry of Health, Labour, and Welfare","award":["H26-Nanchitoo (Nan)-ippann-076, YI"],"award-info":[{"award-number":["H26-Nanchitoo (Nan)-ippann-076, YI"]}]},{"name":"National Hospital Organization Respiratory Diseases Network","award":["H26-NHO (Kokyu)-01"],"award-info":[{"award-number":["H26-NHO (Kokyu)-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Lymphangioleiomyomatosis (LAM) is a diffuse cystic lung disease that occurs in women of childbearing age. LAM can be diagnosed on a clinical basis in patients with typical high\u2010resolution computed tomography (HRCT) patterns and at least one other corroborating disease feature, such as chylothorax, angiomyolipoma, tuberous sclerosis complex or elevated serum vascular endothelial growth factor (VEGF)\u2010D. However, patients who do not meet these criteria require tissue confirmation for a definitive diagnosis, and the utility of methods that are less invasive than surgical lung biopsy, such as transbronchial lung biopsy (TBLB), are not well studied. We retrospectively studied the efficacy and safety of TBLB for the diagnosis of LAM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 1991 to August 2015, 131 consecutive LAM patients were prospectively registered in our study, and a TBLB was conducted for 24 patients. We retrospectively studied the yield and safety of TBLB in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 24 patients were women; the median age was 42\u2009years. HRCT showed multiple round thin\u2010walled cysts diffusely scattered throughout the lungs. The median level of serum VEGF\u2010D was 2109\u2009pg\/mL. Characteristic pathological findings for LAM were identified in 17 patients (70.8%) by two expert pathologists. The %predicted value for diffusing capacity of carbon monoxide was significantly lower in the 17 TBLB\u2010positive LAM patients compared to the seven TBLB\u2010negative LAM patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.046). There were no serious adverse events such as pneumothorax or uncontrollable bleeding due to TBLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TBLB is a safe and effective method for the pathological diagnosis of LAM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13190","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T16:16:40Z","timestamp":1506615400000},"page":"331-338","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy and safety of transbronchial lung biopsy for the diagnosis of lymphangioleiomyomatosis: A report of 24 consecutive patients"],"prefix":"10.1111","volume":"23","author":[{"given":"Taro","family":"Koba","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"},{"name":"Department of Respiratory Medicine, Allergy and Rheumatic Diseases Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Arai","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kitaichi","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Minami Wakayama Medical Center  Tanabe Japan"},{"name":"Department of Pathology National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Hirose","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunobu","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"},{"name":"Clinical Research Center National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikatoshi","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Division of Clinical Trial National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Akira","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"},{"name":"Department of Radiology National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-874X","authenticated-orcid":false,"given":"Yoshikazu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital Organization Kinki\u2010Chuo Chest Medical Center  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-3383-5.00069-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201205-0848OE"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00076209"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201607-1384ST"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0573"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.0225"},{"key":"e_1_2_7_8_1","first-page":"280","article-title":"Comparison of transbronchial and open biopsies in chronic infiltrative lung diseases","volume":"123","author":"Wall CP","year":"1981","journal-title":"Am. 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