{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:53:28Z","timestamp":1756385608199},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Birt\u2013Hogg\u2013Dub\u00e9 syndrome (BHDS) is a rare hereditary disease that presents with multiple lung cysts and pneumothorax (PTX). Although some reports propose that findings from chest computed tomography enable one to distinguish BHDS from primary spontaneous pneumothorax (PSP), it is still unclear whether clinical features are useful for identifying patients with suspicion of BHDS from those with PTX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the medical records of patients with PTX who underwent video\u2010assisted thoracoscopic surgery at Nissan Tamagawa Hospital from January 2012 to December 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified a total of 1141 patients with PTX, including 54 with BHDS and 517 with PSP. Among them, logistic regression analysis segregated five features that were significantly associated with BHDS: familial history of PTX, past history of bilateral PTX, age at the first episode of PTX (\u226525 years old (y.o.)), body mass index (\u226518.5) and gender (female). We assigned scores of 3, 3, 2, 2 and 1 to the five features, respectively, to establish a system with a calculated score from 0 to 11. The cut\u2010off value of a calculated score \u2265 4 yielded the highest sensitivity of 93% and specificity of 86%. Receiver operating characteristic (ROC) analysis showed the area under the curve reflecting an accuracy of this diagnostic test as 0.953.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BHDS has several clinical features distinct from PSP. Our scoring system consists of only five clinical variables that are easily evaluated and efficiently separate BHDS patients from those who have PTX without relying on an imaging study. Further prospective study is needed to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13191","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:47:03Z","timestamp":1506613623000},"page":"414-418","source":"Crossref","is-referenced-by-count":15,"title":["Novel clinical scoring system to identify patients with pneumothorax with suspicion for Birt\u2013Hogg\u2013Dub\u00e9 syndrome"],"prefix":"10.1111","volume":"23","author":[{"given":"Hiroki","family":"Ebana","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine Juntendo University Faculty of Medicine and Graduate School of Medicine  Tokyo Japan"},{"name":"Pneumothorax Research Center and Division of Thoracic Surgery Nissan Tamagawa Hospital  Tokyo Japan"},{"name":"The Study Group for Pneumothorax and Cystic Lung Diseases  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruaki","family":"Mizobuchi","sequence":"additional","affiliation":[{"name":"Pneumothorax Research Center and Division of Thoracic Surgery Nissan Tamagawa Hospital  Tokyo Japan"},{"name":"The Study Group for Pneumothorax and Cystic Lung Diseases  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Pneumothorax Research Center and Division of Thoracic Surgery Nissan Tamagawa Hospital  Tokyo Japan"},{"name":"The Study Group for Pneumothorax and Cystic Lung Diseases  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Juntendo University Faculty of Medicine and Graduate School of Medicine  Tokyo Japan"},{"name":"The Study Group for Pneumothorax and Cystic Lung Diseases  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Haga","sequence":"additional","affiliation":[{"name":"The Study Group for Pneumothorax and Cystic Lung Diseases  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Juntendo University Faculty of Medicine and Graduate School of Medicine  Tokyo Japan"},{"name":"The Study Group for Pneumothorax and Cystic Lung Diseases  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Juntendo University Faculty of Medicine and Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniaki","family":"Seyama","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Juntendo University Faculty of Medicine and Graduate School of Medicine  Tokyo Japan"},{"name":"The Study Group for Pneumothorax and Cystic Lung Diseases  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582068"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1001\/archderm.1977.01640120042005","article-title":"Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons","volume":"113","author":"Birt AR","year":"1977","journal-title":"Arch. 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