{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:41:02Z","timestamp":1785260462325,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Talc pleurodesis is commonly performed to manage refractory pleural effusion or pneumothorax. It is considered as a safe procedure as long as a limited amount of large particle size talc is used. However, acute respiratory distress syndrome (ARDS) is a rare but serious complication after talc pleurodesis. We sought to determine the risk factors for the development of ARDS after pleurodesis using a limited amount of large particle size talc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed patients who underwent pleurodesis with talc or OK\u2010432 at the University of Tokyo Hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven and 35 patients underwent chemical pleurodesis using large particle size talc (4\u2009g or less) or OK\u2010432, respectively. Four of 27 (15%) patients developed ARDS after talc pleurodesis. Patients who developed ARDS were significantly older than those who did not (median 80 vs 66\u2009years, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and had a higher prevalence of underlying interstitial abnormalities on chest computed tomography (CT; 2\/4 vs 1\/23, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). No patient developed ARDS after pleurodesis with OK\u2010432. This is the first case series of ARDS after pleurodesis using a limited amount of large particle size talc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Older age and underlying interstitial abnormalities on chest CT seem to be risk factors for developing ARDS after talc pleurodesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13192","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T04:46:43Z","timestamp":1507178803000},"page":"55-59","source":"Crossref","is-referenced-by-count":23,"title":["Old age and underlying interstitial abnormalities are risk factors for development of ARDS after pleurodesis using limited amount of large particle size talc"],"prefix":"10.1111","volume":"23","author":[{"given":"Yuki","family":"Shinno","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3658-4442","authenticated-orcid":false,"given":"Hidenori","family":"Kage","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Chino","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-3955","authenticated-orcid":false,"given":"Yosuke","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goh","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahide","family":"Nagase","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5535"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60848-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62170-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.02.017"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.3.801"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.9281"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2003.09.014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1843.2000.00235.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2007.07.009"},{"key":"e_1_2_6_11_1","first-page":"1495","article-title":"Randomized phase II trial of OK\u2010432 in patients with malignant pleural effusion due to non\u2010small cell lung cancer","volume":"26","author":"Kasahara K","year":"2006","journal-title":"Anticancer Res."},{"key":"e_1_2_6_12_1","first-page":"CD010529","article-title":"Interventions for the management of malignant pleural effusions: a network meta\u2010analysis","volume":"5","author":"Clive AO","year":"2016","journal-title":"Cochrane Database Syst. 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