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OSA is heritable, and there is evidence of both direct genetic contributions to OSA susceptibility and indirect contributions via \u2018intermediate\u2019 phenotypes such as obesity, craniofacial structure, neurological control of upper airway muscles and of sleep and circadian rhythm. Investigation of the genetics of OSA is an important research area and may lead to improved understanding of disease aetiology, pathogenesis, adverse health consequences and new preventive strategies and treatments. Genetic studies of OSA have lagged behind other chronic diseases; however recent gene discovery efforts have been successful in finding genetic loci contributing to OSA\u2010associated intermediate phenotypes. Nevertheless, many of the seminal questions relating to the genetic epidemiology of OSA and associated factors remain unanswered. This paper reviews the current state of knowledge of the genetics of OSA, with a focus on genomic approaches to understanding sleep apnoea.<\/jats:p>","DOI":"10.1111\/resp.13212","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:02:38Z","timestamp":1510099358000},"page":"18-27","source":"Crossref","is-referenced-by-count":101,"title":["The genetics of obstructive sleep apnoea"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5021-1648","authenticated-orcid":false,"given":"Sutapa","family":"Mukherjee","sequence":"first","affiliation":[{"name":"Sleep Health Service, Respiratory and Sleep Services Southern Adelaide Local Health Network  Adelaide South Australia Australia"},{"name":"Adelaide Institute for Sleep Health Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Saxena","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine and Department of Anesthesia, Pain, and Critical Care Medicine Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Medical and Population Genetics Broad Institute  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle J.","family":"Palmer","sequence":"additional","affiliation":[{"name":"School of Public Health University of Adelaide, North Terrace  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9048(03)00044-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2001.00787.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.2.8049836"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.5.7735600"},{"key":"e_1_2_9_7_1","first-page":"187","article-title":"Epidemiology of obstructive sleep apnea syndrome","volume":"95","author":"Ferini\u2010Strambi L","year":"2004","journal-title":"Minerva Med."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-012-0785-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3283659e1e"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14177"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1500523"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.2003.015859"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.5.1281"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1366"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2002.00256.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00120012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(08)70013-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.4.467"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00043210"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21121"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0448OC"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05911"},{"key":"e_1_2_9_24_1","first-page":"277","article-title":"Sequential tests for the detection of linkage","volume":"7","author":"Morton NE","year":"1956","journal-title":"Am. 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