{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:00:20Z","timestamp":1779314420413,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000659","name":"Research Trainees Coordinating Centre","doi-asserted-by":"publisher","award":["DRF\u20102014\u201007\u2010089"],"award-info":[{"award-number":["DRF\u20102014\u201007\u2010089"]}],"id":[{"id":"10.13039\/501100000659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["DRF\u20102015\u201008\u2010004"],"award-info":[{"award-number":["DRF\u20102015\u201008\u2010004"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["DRF\u20102014\u201007\u2010089"],"award-info":[{"award-number":["DRF\u20102014\u201007\u2010089"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Usual gait speed over 4\u2009m (4MGS) is an established functional performance measure in older adults that consistently predicts adverse health outcomes, but few data exist in idiopathic pulmonary fibrosis (IPF). We assessed the reliability of 4MGS, its relationship with established outcome measures and its responsiveness to pulmonary rehabilitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In four prospective IPF cohorts, 4MGS inter\u2010observer (<jats:italic>n<\/jats:italic>\u2009=\u200946) and test\u2013retest (<jats:italic>n<\/jats:italic>\u2009=\u200946) reliability, concurrent validity (<jats:italic>n<\/jats:italic>\u2009=\u200965 and <jats:italic>n<\/jats:italic>\u2009=\u200962) and responsiveness (<jats:italic>n<\/jats:italic>\u2009=\u200960) were determined. The phenotypic characteristics of all patients stratified according to slow 4MGS (&lt;0.8\u2009m\/s) were compared, including lung function parameters, HRCT of the chest, 6\u2010min walking distance (6MWD), Medical Respiratory Council (MRC) dyspnoea score, King\u2019s Brief Interstitial Lung Disease (KBILD) questionnaire and Gender, Age and lung Physiology (GAP) prognostic index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intra\u2010class correlation coefficients for inter\u2010observer and test\u2013retest reliability were 0.996 and 0.983, respectively. There was a strong association between 4MGS and 6MWD (<jats:italic>r<\/jats:italic>\u2009=\u20090.76; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and moderate correlations with MRC (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.56), KBILD (<jats:italic>r<\/jats:italic>\u2009=\u20090.44) and GAP index (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.41); all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005. 4MGS improved significantly with pulmonary rehabilitation (mean (95% CI) change: 0.16 (0.12\u20130.20) m\/s), effect size 0.65. Patients with slow 4MGS had significantly worse exercise performance (6MWD: \u2212167 (\u2212220 to \u2212133) m), dyspnoea, health status and prognosis index than those with preserved 4MGS, despite similar lung function and HRCT parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>4MGS is a simple, reliable, valid and responsive tool that may detect a patient phenotype with worse exercise performance, dyspnoea, health status and prognosis index in stable IPF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13213","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T01:36:40Z","timestamp":1510709800000},"page":"498-506","source":"Crossref","is-referenced-by-count":26,"title":["Phenotypic characteristics associated with slow gait speed in idiopathic pulmonary fibrosis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-599X","authenticated-orcid":false,"given":"Claire M.","family":"Nolan","sequence":"first","affiliation":[{"name":"Harefield Pulmonary Rehabilitation and Muscle Research Group Royal Brompton and Harefield NHS Foundation Trust  London UK"},{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-0952","authenticated-orcid":false,"given":"Matthew","family":"Maddocks","sequence":"additional","affiliation":[{"name":"Division of Palliative Care, Policy and Rehabilitation King\u2019s College London, Cicely Saunders Institute  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby M.","family":"Maher","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Unit Royal Brompton and Harefield NHS Foundation Trust  London UK"},{"name":"Fibrosis Research Group National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane L.","family":"Canavan","sequence":"additional","affiliation":[{"name":"Harefield Pulmonary Rehabilitation and Muscle Research Group Royal Brompton and Harefield NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Harefield Pulmonary Rehabilitation and Muscle Research Group Royal Brompton and Harefield NHS Foundation Trust  London UK"},{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth E.","family":"Barker","sequence":"additional","affiliation":[{"name":"Harefield Pulmonary Rehabilitation and Muscle Research Group Royal Brompton and Harefield NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhani","family":"Patel","sequence":"additional","affiliation":[{"name":"Harefield Pulmonary Rehabilitation and Muscle Research Group Royal Brompton and Harefield NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Jacob","sequence":"additional","affiliation":[{"name":"Fibrosis Research Group National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cullinan","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.\u2010C.","family":"Man","sequence":"additional","affiliation":[{"name":"Harefield Pulmonary Rehabilitation and Muscle Research Group Royal Brompton and Harefield NHS Foundation Trust  London UK"},{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"NICE. 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