{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:05:54Z","timestamp":1762607154334,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>The relationship between vitamin D and respiratory disease was examined by cross\u2010sectional analysis of a large community\u2010based sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum 25\u2010hydroxyvitamin D (25OHD) and history of respiratory disease, symptoms (recorded by questionnaire) and spirometry were measured in 5011 adults aged 45\u201369\u2009years. Adjustments were made for age, sex, season and smoking (Model A), plus body mass index (BMI) and physical activity level (Model B), plus history of chronic diseases (Model C).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean (SD) age was 58 (SD 6) years with 45% males, 10% current smokers and 12% taking vitamin D supplements. The prevalence of 25OHD level &lt;50\u2009nmol\/L was 8.0%. In all the three models, 25OHD\u2009&lt;50\u2009nmol\/L was significantly associated with asthma (Model C: odds ratio (OR): 1.32; 95% CI: 1.00, 1.73), bronchitis (1.54; 1.17, 2.01), wheeze (1.37; 1.10, 1.71) and chest tightness (1.42; 1.10, 1.83). Participants with vitamin D level\u2009&gt;\u2009100\u2009nmol\/L had higher forced vital capacity (FVC) in all the three models (1.17% higher, compared with the 50\u2013100\u2009nmol\/L group in Model C).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low levels of serum 25OHD were independently associated with asthma, bronchitis, wheeze and chest tightness after three levels of adjustment for potential confounders. Higher vitamin D levels were associated with higher levels of lung function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13239","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:32:41Z","timestamp":1516840361000},"page":"576-582","source":"Crossref","is-referenced-by-count":18,"title":["Vitamin D and respiratory health in the Busselton Healthy Ageing Study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7480-4835","authenticated-orcid":false,"given":"Siobhain","family":"Mulrennan","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"School of Medicine and Pharmacology University of Western Australia  Perth WA Australia"},{"name":"Busselton Population Medical Research Institute Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Knuiman","sequence":"additional","affiliation":[{"name":"Busselton Population Medical Research Institute Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"School of Population and Global Health University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Walsh","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia  Perth WA Australia"},{"name":"Busselton Population Medical Research Institute Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennie","family":"Hui","sequence":"additional","affiliation":[{"name":"Busselton Population Medical Research Institute Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"School of Population and Global Health University of Western Australia  Perth WA Australia"},{"name":"PathWest Laboratory Medicine  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hunter","sequence":"additional","affiliation":[{"name":"Busselton Population Medical Research Institute Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"School of Population and Global Health University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Divitini","sequence":"additional","affiliation":[{"name":"School of Population and Global Health University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia  Perth WA Australia"},{"name":"Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian R.","family":"Cooke","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur W. (Bill)","family":"Musk","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"School of Medicine and Pharmacology University of Western Australia  Perth WA Australia"},{"name":"Busselton Population Medical Research Institute Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"School of Population and Global Health University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"James","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia  Perth WA Australia"},{"name":"Busselton Population Medical Research Institute Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"Department of Pulmonary Physiology and Sleep Medicine Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70165-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.111.000398"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202139"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0356OC"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.065"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.12.009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2011.07.003"},{"key":"e_1_2_8_9_1","first-page":"CD011511","article-title":"Vitamin D for the management of asthma","volume":"9","author":"Martineau AR","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00146509"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053670"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268806007175"},{"key":"e_1_2_8_13_1","first-page":"1204","article-title":"Exacerbations of chronic obstructive pulmonary disease","volume":"48","author":"Wedzicha JA","year":"2003","journal-title":"Respir. Care"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465815618113"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2932"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0641-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","unstructured":"JamesA HunterM StrakerL BeilbyJ BucksR DavisT EikelboomRH HillmanD HuiJ HungJet al.;Busselton Healthy Ageing Study Investigator Group. Rationale design and methods for a community\u2010based study of clustering and cumulative effects of chronic disease processes and their effects on ageing: the Busselton Healthy Ageing Study.BMC Public Health2013;13:936.","DOI":"10.1186\/1471-2458-13-936"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6132.241"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/02701367.2000.11082794"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9712108"},{"key":"e_1_2_8_21_1","unstructured":"MillerMR HankinsonJ BrusascoV BurgosF CasaburiR CoatesA CrapoR EnrightP van derGrintenCP GustafssonPet al.;ATS\/ERS Task Force. Standardisation of spirometry.Eur. Respir. J.2005;26:319\u201338."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563215625693"},{"volume-title":"Dietary Reference Intakes for Calcium and Vitamin D","year":"2011","author":"Ross AC","key":"e_1_2_8_23_1"},{"key":"e_1_2_8_24_1","first-page":"2880","article-title":"Vitamin D deficiency and the lung: disease initiator or disease modifier?","volume":"5","author":"Foong RE","year":"2013","journal-title":"Forum Nutr."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12538"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201312-423OC"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000174"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0716"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.560"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065835"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6.3792"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5430"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6554"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.234"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665114001578"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.12.006"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.140921"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1086\/527488"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3045"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.13239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:29:17Z","timestamp":1695508157000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.13239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,24]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/resp.13239"],"URL":"https:\/\/doi.org\/10.1111\/resp.13239","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"type":"print","value":"1323-7799"},{"type":"electronic","value":"1440-1843"}],"subject":[],"published":{"date-parts":[[2018,1,24]]}}}