{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:43:20Z","timestamp":1792799000740,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:00:00Z","timestamp":1517529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001078","name":"Queensland Emergency Medicine Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001078","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common presentation to emergency departments (ED) but data regarding its epidemiology and outcomes are scarce. We describe the epidemiology, clinical features, treatment and outcome of patients treated for AECOPD in ED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a planned sub\u2010study of patients with an ED diagnosis of AECOPD identified in the Asia, Australia and New Zealand Dyspnoea in Emergency Departments (AANZDEM) study. The AANZDEM was a prospective, interrupted time series cohort study conducted in 46 ED in Australia, New Zealand, Singapore, Hong Kong and Malaysia over three 72\u2010h periods in May, August and October 2014. Primary outcomes were patient epidemiology, clinical features, treatment and outcomes (hospital length of stay (LOS) and mortality).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six ED participated. There were 415 patients with an ED primary diagnosis of AECOPD (13.6% of the overall cohort; 95% CI: 12.5\u201314.9%). Median age was 73 years, 60% males and 65% arrived by ambulance. Ninety\u2010one percent had an existing COPD diagnosis. Eighty percent of patients received inhaled bronchodilators, 66% received systemic corticosteroids and 57% of those with pH &lt; 7.30 were treated with non\u2010invasive ventilation (NIV). Seventy\u2010eight percent of patients were admitted to hospital, 7% to an intensive care unit. In\u2010hospital mortality was 4% and median LOS was 4 days (95% CI: 2\u20137).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients treated in ED for AECOPD commonly arrive by ambulance, have a high admission rate and significant in\u2010hospital mortality. Compliance with evidence\u2010based treatments in ED is suboptimal affording an opportunity to improve care and potentially outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13259","type":"journal-article","created":{"date-parts":[[2018,2,3]],"date-time":"2018-02-03T00:32:34Z","timestamp":1517617954000},"page":"681-686","source":"Crossref","is-referenced-by-count":24,"title":["Epidemiology, treatment, disposition and outcome of patients with acute exacerbation of COPD presenting to emergency departments in Australia and South East Asia: An AANZDEM study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-5023","authenticated-orcid":false,"given":"Anne Maree","family":"Kelly","sequence":"first","affiliation":[{"name":"Joseph Epstein Centre for Emergency Medicine Sunshine Hospital  St Albans VIC Australia"},{"name":"School of Medicine \u2013 Western Clinical School The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Holdgate","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Liverpool Hospital  Sydney NSW Australia"},{"name":"University of New South Wales (Southwest Clinical School)  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben","family":"Keijzers","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Gold Coast University Hospital  Gold Coast QLD Australia"},{"name":"School of Medicine Bond University  Gold Coast QLD Australia"},{"name":"School of Medicine Griffith University  Gold Coast QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Klim","sequence":"additional","affiliation":[{"name":"Joseph Epstein Centre for Emergency Medicine Sunshine Hospital  St Albans VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin A.","family":"Graham","sequence":"additional","affiliation":[{"name":"Chinese University of Hong Kong Prince of Wales Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Craig","sequence":"additional","affiliation":[{"name":"Emergency Department Monash Medical Centre  Melbourne VIC Australia"},{"name":"School of Clinical Sciences Monash University  Melbourne VIC Australia"},{"name":"Murdoch Children's Research Institute  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-7842","authenticated-orcid":false,"given":"Win Sen","family":"Kuan","sequence":"additional","affiliation":[{"name":"Emergency Medicine Department National University Health System  Singapore"},{"name":"Department of Surgery, Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Auckland City Hospital  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Lawoko","sequence":"additional","affiliation":[{"name":"Industry Doctoral Training Centre ATN Universities  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"Laribi","sequence":"additional","affiliation":[{"name":"Emergency Medicine Department Tours University Hospital, Fran\u00e7ois\u2010Rabelais University  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0319-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2015.1043517"},{"key":"e_1_2_7_4_1","unstructured":"AbramsonMJ CrockettAJ DabscheckEJ FrithPA GeorgeJ GlasgowN JenkinsSC McDonaldCF McDonaldVM McKenzieDet al. The COPDX Plan: Australian and New Zealand Guidelines for the Management of Chronic Obstructive Pulmonary Disease Version 2.39 October 2014. [Accessed 2 Feb 2015.] Available from URL:http:\/\/www.copdx.org.au\/"},{"key":"e_1_2_7_5_1","article-title":"Compliance with a COPD bundle of care in an Australian emergency department: a cohort study","author":"Gerber A","year":"2016","journal-title":"Clin. Respir. J."},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","unstructured":"KellyAM KeijzersG KlimS GrahamC CraigS KuanWS JonesP HoldgateA LawokoC LaribiS;AANZDEM Study Group. Australia Asia and New Zealand Dyspnoea in Emergency Departments study (AANZDEM): rationale design and analysis.Emerg. Med. 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