{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:49:46Z","timestamp":1791816586653,"version":"4.3.4"},"reference-count":120,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T00:00:00Z","timestamp":1518912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH 1R21AI127133\u201001"],"award-info":[{"award-number":["NIH 1R21AI127133\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["643381\u2010TBVAC2020\u2010 H2020\u2010PHC\u20102014\u20102015"],"award-info":[{"award-number":["643381\u2010TBVAC2020\u2010 H2020\u2010PHC\u20102014\u20102015"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF\u20102011\u201002348713"],"award-info":[{"award-number":["RF\u20102011\u201002348713"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tuberculosis (TB) remains a devastating disease, yet despite its enormous toll on global health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB\u2010BM) would constitute extremely useful tools to measure infection status and predict outcome of infection, vaccination or therapy. There are several types of TB\u2010BM: Correlate of Infection; Correlate of TB Disease; Correlate of Increased Risk of Developing Active TB Disease; Correlate of the Curative Response to Therapy; and Correlate of Protection (CoP). Most TB\u2010BM currently studied are host\u2010derived BM, and consist of transcriptomic, proteomic, metabolomic, cellular markers or marker combinations (\u2018signatures\u2019). In particular, vaccine\u2010inducible CoP are expected to be transformative in developing new TB vaccines as they will de\u2010risk vaccine research and development (R&amp;D) as well as human testing at an early stage. In addition, CoP could also help minimizing the need for preclinical studies in experimental animals.<\/jats:p>\n                  <jats:p>Of key importance is that TB\u2010BM are tested and validated in different well\u2010characterized human TB cohorts, preferably with complementary profiles and geographically diverse populations: genetic and environmental factors such as (viral) coinfections, exposure to non\u2010tuberculous mycobacteria, nutritional status, metabolic status, age (infants vs children vs adolescents vs adults) and other factors impact host immune set points and host responses across different populations.<\/jats:p>\n                  <jats:p>In this study, we review the most recent advances in research into TB\u2010BM for the diagnosis of active TB, risk of TB development and treatment\u2010induced TB cure.<\/jats:p>","DOI":"10.1111\/resp.13272","type":"journal-article","created":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T21:02:55Z","timestamp":1518987775000},"page":"455-466","source":"Crossref","is-referenced-by-count":156,"title":["Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-4376","authenticated-orcid":false,"given":"Delia","family":"Goletti","sequence":"first","affiliation":[{"name":"Translational Research Unit, Department of Epidemiology and Preclinical Research National Institute for Infectious Diseases \u201cL. Spallanzani\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Rui","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3406-366X","authenticated-orcid":false,"given":"Jann\u2010Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Colorado School of Public Health Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3706-3403","authenticated-orcid":false,"given":"Tom H.M.","family":"Ottenhoff","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,18]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO. Tuberculosis fact sheet 2017. Available from URL:http:\/\/www.who.int\/mediacentre\/factsheets\/fs104\/en\/"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002152"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/651492"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140095"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.01.018"},{"key":"e_1_2_9_7_1","unstructured":"ZellwegerJP SotgiuG BlockM DoreS AltetN BlunschiR BogyiM BothamleyG BotheC CodecasaLet al.;TBNET. Risk assessment of tuberculosis in contacts by IFN\u2010gamma release assays. A Tuberculosis Network European Trials Group Study.Am. J. Respir. Crit. Care Med.2015;191:1176\u201384."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043739"},{"key":"e_1_2_9_9_1","first-page":"1226","article-title":"The diagnosis and misdiagnosis of tuberculosis","volume":"12","author":"Davies PD","year":"2008","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"e_1_2_9_10_1","unstructured":"WHO. High\u2010priority target product profiles for new tuberculosis diagnostics. Report of a consensus meeting 2014. Available from URL:http:\/\/www.who.int\/tb\/publications\/tpp_report\/en\/"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu821"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.113989"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2011.03.004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-013-0077-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw545"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.3651"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e32833ed177"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01317-15"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"e0150755","DOI":"10.1371\/journal.pone.0150755","article-title":"Molecular diagnosis of urinary tract infections by semi\u2010quantitative detection of uropathogens in a routine clinical hospital setting","volume":"11","author":"Zee A","year":"2016","journal-title":"PLoS One"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004100"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70149-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2016.01.001"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-333"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09895-7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0822-8"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00025711"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-7-74"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1128\/IAI.67.2.581-588.1999","article-title":"Pathophysiology of antigen 85 in patients with active tuberculosis: antigen 85 circulates as complexes with fibronectin and immunoglobulin G","volume":"67","author":"Bentley\u2010Hibbert SI","year":"1999","journal-title":"Infect. Immun."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621360114"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00175113"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09247"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","unstructured":"AndersonST KaforouM BrentAJ WrightVJ BanwellCM ChagalukaG CrampinAC DockrellHM FrenchN HamiltonMSet al.;ILULU Consortium;KIDS TB Study Group. Diagnosis of childhood tuberculosis and host RNA expression in Africa. N. Engl. J. Med.2014;370:1712\u201323.","DOI":"10.1056\/NEJMoa1303657"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070630"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001538"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2012.06.002"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.12.0479"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-9792(12)70007-0"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)00048-5"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2010.51"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040221"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","unstructured":"ChegouNN SutherlandJS MalherbeS CrampinAC CorstjensPL GelukA Mayanja\u2010KizzaH LoxtonAG van derSpuyG StanleyKet al.;AE\u2010TBC Consortium. Diagnostic performance of a seven\u2010marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB. Thorax2016;71:785\u201394.","DOI":"10.1136\/thoraxjnl-2015-207999"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","unstructured":"CorstjensPL Tjon Kon FatEM deDoodCJ van derPloeg\u2010van SchipJJ FrankenKL ChegouNN SutherlandJS HoweR MihretA KassaDet al.;AE\u2010TBC Consortium. Multi\u2010center evaluation of a user\u2010friendly lateral flow assay to determine IP\u201010 and CCL4 levels in blood of TB and non\u2010TB cases in Africa.Clin. Biochem.2016;49:22\u201331.","DOI":"10.1016\/j.clinbiochem.2015.08.013"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4161"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11290"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064226"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.09.004"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-013-9979-x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002845"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003901"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/589471"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004209"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.02.008"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.16.0342"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120012"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160546"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/981984"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737768"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040455"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.02.004"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.06.009"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2299"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit265"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1086\/507427"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.07.009"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70884-9"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043733"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77990"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201243262"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu795"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.09.027"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit494"},{"key":"e_1_2_9_72_1","doi-asserted-by":"crossref","unstructured":"NaranbhaiV MoodleyD ChipatoT Stranix\u2010ChibandaL NakabaiitoC KamateekaM MusokeP ManjiK GeorgeK EmelLMet al.;HPTN 046 Protocol Team. The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV\u2010infected postpartum women. J. Acquir. Immune Defic. Syndr.2014;67:573\u20135.","DOI":"10.1097\/QAI.0000000000000353"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171358"},{"key":"e_1_2_9_74_1","unstructured":"WHO. Commercial serodiagnostic tests for diagnosis of tuberculosis: policy statement. WHO Library Cataloguing\u2010in\u2010Publication Data 2011. Available from URL:http:\/\/www.tbcindia.nic.in\/pdfs\/WHO_Policy_Serology_2011.pdf"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001062"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181414"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173359"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69342-2"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2010.01.003"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.08.003"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.12.006"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2236"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.69"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0531-3"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140097"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01012-2016"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70210-9"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ612"},{"key":"e_1_2_9_89_1","unstructured":"ZakDE Penn\u2010NicholsonA ScribaTJ ThompsonE SulimanS AmonLM MahomedH ErasmusM WhatneyW HusseyGDet al.;ACS and GC6\u201074 Cohort Study Groups. A blood RNA signature for tuberculosis disease risk: a prospective cohort study.Lancet2016;387:2312\u201322."},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.08.006"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2014.12.001"},{"key":"e_1_2_9_92_1","unstructured":"TamerisMD HatherillM LandryBS ScribaTJ SnowdenMA LockhartS SheaJE McClainJB HusseyGD HanekomWAet al.;MVA85A 020 Trial Study TeamSafety and efficacy of MVA85A a new tuberculosis vaccine in infants previously vaccinated with BCG: a randomised placebo\u2010controlled phase 2b trial.Lancet2013;381:1021\u20138."},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407426"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4177"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.1.2.189"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200210-1125OC"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.4.1062"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70071-2"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0769OC"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01526-09"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.1.9811006"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00547-11"},{"key":"e_1_2_9_103_1","doi-asserted-by":"crossref","unstructured":"FriedrichSO RachowA SaathoffE SinghK ManguCD DawsonR PhillipsPP VenterA BatesonA BoehmeCCet al.;Pan African Consortium for the Evaluation of Anti\u2010tuberculosis Antibiotics (PanACEA). Assessment of the sensitivity and specificity of Xpert MTB\/RIF assay as an early sputum biomarker of response to tuberculosis treatment.Lancet Respir. Med.2013;1:462\u201370.","DOI":"10.1016\/S2213-2600(13)70119-X"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.11.0614"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2302003"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ195"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045839"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0609-3"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv447"},{"key":"e_1_2_9_110_1","first-page":"98","article-title":"Post\u2010treatment changes of six cytokines in active pulmonary tuberculosis: differences between patients with stable or increased fibrosis","volume":"9","author":"Ameglio F","year":"2005","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00381-09"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1572-3"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.09.033"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061333"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001628"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-45"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01084-2016"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01976-2016"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061002"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00430-17"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3187"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.13272","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T18:11:46Z","timestamp":1751393506000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.13272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,18]]},"references-count":120,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/resp.13272"],"URL":"https:\/\/doi.org\/10.1111\/resp.13272","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,18]]}}}