{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:49:13Z","timestamp":1778921353332,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labour, and Welfare, Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>The St George\u2019s Respiratory Questionnaire (SGRQ) is a self\u2010administered questionnaire used to assess health\u2010related quality of life (HRQoL) in various chronic respiratory diseases. Few studies have assessed the performance of the SGRQ in patients with connective tissue disease\u2010associated interstitial lung disease (CTD\u2010ILD). We aimed to examine the SGRQ\u2019s performance characteristics and generate data to support its reliability and validity in patients with CTD\u2010ILD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from 193 CTD\u2010ILD patients evaluated at Tosei General Hospital from May 2007 to July 2016 to assess the cross\u2010sectional and longitudinal validity of the SGRQ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients was 64.2\u2009years and 122 (63.2%) were women. There were no significant differences in SGRQ scores between any of the CTD groups. Internal consistency (Cronbach\u2019s \u03b1\u2009=\u20090.905) and repeatability (intraclass correlation coefficient (ICC)\u2009=\u20090.873) for the SGRQ total score were excellent. At baseline, SGRQ total score was significantly associated with clinically meaningful measures of physiological function, exercise capacity and dyspnoea. Change in SGRQ total score over 6\u2009months was also associated with change in other measures. Cox proportional hazards models showed that higher baseline SGRQ total score was a significant predictor of mortality. The estimated minimal clinically important difference of SGRQ total score was 4\u201313 points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data support the validity and reliability of SGRQ as a sensitive measure for capturing HRQoL in patients with CTD\u2010ILD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13293","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T13:31:26Z","timestamp":1521984686000},"page":"851-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Performance of the St George\u2019s Respiratory Questionnaire in patients with connective tissue disease\u2010associated interstitial lung disease"],"prefix":"10.1111","volume":"23","author":[{"given":"Atsushi","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine and Allergy Tosei General Hospital  Seto Japan"},{"name":"Department of 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