{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:27:34Z","timestamp":1768566454203,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["171101008"],"award-info":[{"award-number":["171101008"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Bronchoscopic lung volume reduction using endobronchial valves (EBV) is an effective new treatment option for severe emphysema patients without interlobar collateral ventilation. The objective of this study was to perform an economic evaluation including the costs and cost\u2010effectiveness of EBV treatment compared with standard medical care (SoC) from the hospital perspective in the short term and long term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For the short\u2010term evaluation, incremental cost\u2010effectiveness ratios (ICER) were calculated based on the 6\u2010month end point data from the STELVIO randomized trial. For the long\u2010term evaluation, a Markov simulation model was constructed based on STELVIO and literature. The clinical outcome data were quality\u2010adjusted life\u2010years (QALY) based on the EuroQol5\u2010Dimensions (EQ5D) questionnaire, the 6\u2010min walking distance (6MWD) and the St George\u2019s Respiratory Questionnaire (SGRQ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean difference between the EBV group and controls was \u20ac16\u2009721\/patient. In the short\u2010term (6\u2009months), costs per additional QALY was \u20ac205\u2009129, the ICER for 6MWD was \u20ac160 and for SGRQ was \u20ac1241. In the long term, the resulting cost\u2010effectiveness ratios indicate additional costs of \u20ac39\u2009000 per QALY gained with a 5\u2010year time horizon and \u20ac21\u2009500 per QALY gained at 10\u2009years. In comparison, historical costs per additional QALY 1\u2009year after the coil treatment are \u20ac738\u2009400, 5\u2009years after lung volume reduction surgery are \u20ac48\u2009415 and 15\u2009years after double\u2010lung transplantation are \u20ac29\u2009410.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The positive clinical effects of EBV treatment are associated with increased costs compared with SoC. Our results suggest that the EBV treatment has a favourable cost\u2010effectiveness profile, also when compared with other treatment modalities for this patient group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13295","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T13:31:20Z","timestamp":1521984680000},"page":"835-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cost\u2010effectiveness of endobronchial valve treatment in patients with severe emphysema compared to standard medical care"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-9673","authenticated-orcid":false,"given":"Jorine E.","family":"Hartman","sequence":"first","affiliation":[{"name":"Department of Pulmonary Diseases University of Groningen, University Medical Centre Groningen Groningen The Netherlands"},{"name":"Groningen Research Institute for Asthma and COPD University of Groningen, University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Klooster","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases University of Groningen, University Medical Centre Groningen Groningen The Netherlands"},{"name":"Groningen Research Institute for Asthma and COPD University of Groningen, University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk","family":"Groen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Groningen, University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick H.T.","family":"ten Hacken","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases University of Groningen, University Medical Centre Groningen Groningen The Netherlands"},{"name":"Groningen Research Institute for Asthma and COPD University of Groningen, University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk\u2010Jan","family":"Slebos","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases University of Groningen, University Medical Centre Groningen Groningen The Netherlands"},{"name":"Groningen Research Institute for Asthma and COPD University of Groningen, University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507807"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.06.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000453529"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","unstructured":"KempSV SlebosDJ KirkA KornaszewskaM CarronK EkL BromanG HillerdalG MalH PisonCet al.;TRANSFORM Study Team. A multicenter RCT of zephyr(R) endobronchial valve treatment in heterogeneous emphysema (TRANSFORM).Am. J. Respir. Crit. Care Med.2017;196:1535\u201343.","DOI":"10.1164\/rccm.201707-1327OC"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","unstructured":"ValipourA SlebosDJ HerthF DarwicheK WagnerM FickerJH PetermannC HubnerRH StanzelF EberhardtR;IMPACT Study Team. Endobronchial valve therapy in patients with homogeneous emphysema. Results from the IMPACT study.Am. J. Respir. Crit. Care Med.2016;194:1073\u201382.","DOI":"10.1164\/rccm.201607-1383OC"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2017.02.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368088"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.1124"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(06)80166-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2010.09.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1050(199707)6:4<327::AID-HEC282>3.0.CO;2-W"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.06.012"},{"key":"e_1_2_7_16_1","unstructured":"Statistics Netherlands. [Accessed 1 September 2017]. Available from URL:www.cbs.nl."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465815589904"},{"key":"e_1_2_7_18_1","unstructured":"SciurbaFC CrinerGJ StrangeC ShahPL MichaudG ConnollyTA Desl\u00e9eG TillisWP DelageA MarquetteCHet al.;RENEW Study Research Group. Effect of endobronchial coils vs usual care on exercise tolerance in patients with severe emphysema: the RENEW randomized clinical trial.JAMA2016;315:2178\u201389."},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","unstructured":"Desl\u00e9eG MalH DutauH BourdinA VergnonJM PisonC KesslerR JounieauxV ThibervilleL LeroySet al.;REVOLENS Study Group. Lung volume reduction coil treatment vs usual care in patients with severe emphysema: the REVOLENS randomized clinical trial.JAMA2016;315:175\u201384.","DOI":"10.1001\/jama.2015.17821"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1790"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.120342"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0852LE"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.13295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T12:07:36Z","timestamp":1720181256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.13295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,25]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/resp.13295"],"URL":"https:\/\/doi.org\/10.1111\/resp.13295","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,25]]},"assertion":[{"value":"2017-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}