{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:10:19Z","timestamp":1769155819564,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["299901"],"award-info":[{"award-number":["299901"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002193","name":"Lupus Foundation of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Chronic obstructive pulmonary disease (COPD) has potential origins in childhood but an association between childhood measles and post\u2010bronchodilator (BD) airflow obstruction (AO) has not yet been shown. We investigated whether childhood measles contributed to post\u2010BD AO through interactions with asthma and\/or smoking in a non\u2010immunized middle\u2010aged population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The population\u2010based Tasmanian Longitudinal Health Study (TAHS) cohort born in 1961 (<jats:italic>n<\/jats:italic> = 8583) underwent spirometry in 1968 before immunization was introduced. A history of childhood measles infection was obtained from school medical records. During the fifth decade follow\u2010up (<jats:italic>n<\/jats:italic> = 5729 responses), a subgroup underwent further lung function measurements (<jats:italic>n<\/jats:italic> = 1389). Relevant main associations and interactions by asthma and\/or smoking on post\u2010BD forced expiratory volume in 1 s\/forced vital capacity (FEV<jats:sub>1<\/jats:sub>\/FVC; continuous variable) and AO (FEV<jats:sub>1<\/jats:sub>\/FVC &lt; lower limit of normal) were estimated by multiple regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010nine percent (<jats:italic>n<\/jats:italic> = 950) had a history of childhood measles. Childhood measles augmented the combined adverse effect of current clinical asthma and smoking at least 10 pack\u2010years on post\u2010BD FEV<jats:sub>1<\/jats:sub>\/FVC ratio in middle age (z\u2010score: \u22120.70 (95% CI: \u22121.1 to \u22120.3) vs \u22121.36 (\u22121.6 to \u22121.1), three\u2010way interaction: <jats:italic>P<\/jats:italic> = 0.009), especially for those with childhood\u2010onset asthma. For never\u2010 and ever\u2010smokers of &lt;10 pack\u2010years who had current asthma symptoms, compared with those without childhood measles, paradoxically, the odds for post\u2010BD AO was not significant in the presence of childhood measles (OR: 12.0 (95% CI: 3.4\u201342) vs 2.17 (0.9\u20135.3)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Childhood measles infection appears to compound the associations between smoking, current asthma and post\u2010BD AO. Differences between asthma subgroups provide further insight into the complex aetiology of obstructive lung diseases for middle\u2010aged adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13297","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T04:01:22Z","timestamp":1521604882000},"page":"780-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Childhood measles contributes to post\u2010bronchodilator airflow obstruction in middle\u2010aged adults: A cohort study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-0615","authenticated-orcid":false,"given":"Jennifer L.","family":"Perret","sequence":"first","affiliation":[{"name":"Allergy and Lung Health Unit Centre for Epidemiology and Biostatistics, The University of Melbourne  Melbourne VIC Australia"},{"name":"Department of Respiratory and Sleep Medicine Austin Hospital  Melbourne VIC 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