{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:30:15Z","timestamp":1789083015382,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>There are few studies on the relationship between bronchiectasis and acute coronary syndrome (ACS). We conducted a population\u2010based cohort study to assess whether bronchiectasis was associated with an increased risk of ACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified 3521 patients diagnosed with bronchiectasis between 2000 and 2010 (bronchiectasis cohort) and frequency matched them with 14\u2009084 randomly selected people without bronchiectasis from the general population (comparison cohort) according to sex, age and index year using the Longitudinal Health Insurance Database. Both cohorts were followed until the end of 2010 to determine the ACS incidence. Hazard ratios of ACS were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Based on 17\u2009340 person\u2010years for bronchiectasis patients and 73\u2009639 person\u2010years for individuals without bronchiectasis, the overall ACS risk was 40% higher in the bronchiectasis cohort (adjusted hazard ratio (HR)\u2009=\u20091.40; 95% CI: 1.20\u20131.62). Compared with those in the comparison cohort with one respiratory infection\u2010related emergency room (ER) visit per year, the ACS risk was 5.46\u2010fold greater in bronchiectasis patients with three or more ER visits per year (adjusted HR =\u20095.46, 95% CI: 4.29\u20136.96). Patients with bronchiectasis and three or more respiratory infection\u2010related hospitalizations per year had an 8.15\u2010fold higher ACS risk (adjusted HR\u2009=\u20098.15, 95% CI: 6.27\u201310.61).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bronchiectasis patients, particularly those experiencing frequent exacerbations with three or more ER visits and consequent hospitalization per year, are at an increased ACS risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.13298","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T16:32:26Z","timestamp":1523464346000},"page":"828-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Increased risk of acute coronary syndrome in patients with bronchiectasis: A population\u2010based cohort study"],"prefix":"10.1111","volume":"23","author":[{"given":"Chin\u2010Tun","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Healthcare Administration Central Taiwan University of Science and Technology  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Fen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Healthcare Administration Central Taiwan University of Science and Technology  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-5690","authenticated-orcid":false,"given":"Wei\u2010Sheng","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Healthcare Administration Central Taiwan University of Science and Technology  Taichung Taiwan"},{"name":"Department of Internal Medicine Taichung Hospital, Ministry of Health and Welfare  Taichung Taiwan"},{"name":"Department of Health Services Administration China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs411"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2008.12.022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.633552"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.13.0288"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.03.021"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.07.233"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0092"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012519"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2253011575"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0776"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00119114"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.5.1815"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200050685"},{"key":"e_1_2_7_15_1","first-page":"CD008351","article-title":"Airway clearance techniques for bronchiectasis","volume":"5","author":"Lee AL","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.150885"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1546820"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12278"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00018414"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70213-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479972312459973"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-208188"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcu237"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12599"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2011.284208"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03416.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207415"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12367"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0455PP"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.06.134"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcv015"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.10.013"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071109"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1937"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0872-5"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.029"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph6010209"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S126102"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3667"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.7.1142"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.22.2557"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.13298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:51:02Z","timestamp":1694933462000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.13298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,11]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/resp.13298"],"URL":"https:\/\/doi.org\/10.1111\/resp.13298","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,11]]},"assertion":[{"value":"2017-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}