{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:48:14Z","timestamp":1789678094151,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["10110801"],"award-info":[{"award-number":["10110801"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Unrecognized obstructive sleep apnoea syndrome (OSAS) may lead to poor asthma control despite optimal therapy. We assessed asthma control, airway responsiveness, daytime sleepiness and health status at baseline and 3\u2009months after continuous positive airway pressure (CPAP) treatment among asthma patients with nocturnal symptoms and OSAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with nocturnal asthma symptoms despite receiving at least moderate\u2010dose inhaled corticosteroid and long\u2010acting bronchodilators underwent a home sleep study using \u2018Embletta\u2019 portable diagnostic system. Patients with significant OSAS (apnoea\u2013hypopnoea index (AHI) \u226510\/h) were randomized to receive either CPAP or conservative treatment for 3\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 145 patients recruited, 122 underwent sleep study with 41 (33.6%) having AHI \u226510\/h. Patients with significant OSAS had higher BMI (27.4 (5.1) vs 25.1 (4.5) kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic> =\u20090.016), bigger neck circumference (36.6 (3.1) vs 34.8 (3.6) cm, <jats:italic>P<\/jats:italic> =\u20090.006) and lower minimum SaO<jats:sub>2<\/jats:sub> (80.7 (6.6) vs 87.2 (3.9) %, <jats:italic>P<\/jats:italic> &lt;\u20090.001). Using intention\u2010to\u2010treat analysis among 37 patients with AHI \u226510\/h (CPAP group (<jats:italic>n<\/jats:italic> =\u200917) vs control group (<jats:italic>n<\/jats:italic> =\u200920)), there was no significant difference in Asthma Control Test score (CPAP 3.2 (2.7) vs control 2.4 (5.7), <jats:italic>P<\/jats:italic> =\u20090.568) but the CPAP group had a greater improvement in Epworth Sleepiness Scale (\u22123.0 (4.5) vs 0.5(3.8), <jats:italic>P<\/jats:italic> =\u20090.014), Asthma Quality of Life Questionnaire (0.6 (0.8) vs 0.02 (0.7), <jats:italic>P<\/jats:italic> =\u20090.022) and vitality domain in the SF\u201036 questionnaire (14.7 (16.8) vs 0.3 (16.2), P\u2009=\u20090.012) after 3\u2009months. Data are presented as mean (SD) unless otherwise stated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high prevalence of OSAS was found among patients with asthma and snoring. CPAP therapy for 3\u2009months did not enhance asthma control but improved daytime sleepiness, quality of life and vitality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13363","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T03:04:58Z","timestamp":1531278298000},"page":"1055-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Continuous positive airway pressure for obstructive sleep apnoea does not improve asthma control"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-7312","authenticated-orcid":false,"given":"Susanna S.S.","family":"Ng","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Princes of Wales Hospital  Shatin Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-5846","authenticated-orcid":false,"given":"Tat\u2010On","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Princes of Wales Hospital  Shatin Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin\u2010Wang","family":"To","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Princes of Wales Hospital  Shatin Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken K.P.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Princes of Wales Hospital  Shatin Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Ngai","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Princes of Wales Hospital  Shatin Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing\u2010Ho","family":"Yip","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Princes of Wales Hospital  Shatin Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.P.","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Princes of Wales Hospital  Shatin Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny W.S.","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Princes of Wales Hospital  Shatin Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4382-2445","authenticated-orcid":false,"given":"David S.C.","family":"Hui","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Princes of Wales Hospital  Shatin Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1.62"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2008.01394.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.015867"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1183\/09031936.93.06040531","article-title":"Snoring, asthma and sleep disturbance in Britain: a community\u2010based survey","volume":"6","author":"Fitzpatrick MF","year":"1993","journal-title":"Eur. 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