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This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cross\u2010sectional analysis included 8592 patients without physician\u2010diagnosed hyperlipidaemia or reported intake of a lipid\u2010lowering drug (age 50.1\u2009\u00b1\u200912.7\u2009years, 69.1% male, BMI: 30.8\u2009\u00b1\u20096.6\u2009kg\/m<jats:sup>2<\/jats:sup>, mean apnoea\u2013hypopnoea index (AHI): 25.7\u2009\u00b1\u200925.9 events\/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high\u2010density lipoprotein cholesterol (HDL\u2010C), low\u2010density lipoprotein cholesterol (LDL\u2010C) and fasting triglycerides (TG)) was determined by means of general linear model analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a dose response relationship between TC and ODI (mean\u2009\u00b1\u2009SE (mg\/dL): 180.33\u2009\u00b1\u20092.46, 184.59\u2009\u00b1\u20092.42, 185.44\u2009\u00b1\u20092.42 and 185.73\u2009\u00b1\u20092.44; <jats:italic>P<\/jats:italic> &lt;\u20090.001 across ODI quartiles I\u2013IV). TG and LDL concentrations were better predicted by AHI than by ODI. HDL\u2010C was significantly reduced in the highest AHI quartile (mean\u2009\u00b1\u2009SE (mg\/dL): 48.8\u2009\u00b1\u20091.49 vs 46.50\u2009\u00b1\u20091.48; <jats:italic>P<\/jats:italic> =\u20090.002, AHI quartile I vs IV). Morbid obesity was associated with lower TC and higher HDL\u2010C values. Lipid status was influenced by geographical location with the highest TC concentration recorded in Northern Europe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OSA severity was independently associated with cholesterol and TG concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13372","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T16:17:49Z","timestamp":1534954669000},"page":"1180-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4746-529X","authenticated-orcid":false,"given":"Canan","family":"G\u00fcnd\u00fcz","sequence":"first","affiliation":[{"name":"Department of Chest Diseases Ege University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozen K.","family":"Basoglu","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases Ege University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hedner","sequence":"additional","affiliation":[{"name":"Sleep and Vigilance Laboratory Sahlgrenska Academy  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Zou","sequence":"additional","affiliation":[{"name":"Sleep and Vigilance Laboratory Sahlgrenska Academy  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R.","family":"Bonsignore","sequence":"additional","affiliation":[{"name":"Biomedical Department of Internal and Specialist Medicine (DiBiMIS), Section of Pneumology University of Palermo  Palermo Italy"},{"name":"CNR Institute of Biomedicine and Molecular Immunology  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Hein","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center  Reinbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Staats","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hospital de Santa Maria  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasia","family":"Pataka","sequence":"additional","affiliation":[{"name":"Respiratory Failure Unit G. 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