{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:57:05Z","timestamp":1791633425179,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>A new taxonomic and management approach, termed treatable traits, has been proposed for airway diseases including severe asthma. This study examined whether treatable traits could be identified using registry data and whether particular treatable traits were associated with future exacerbation risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Australasian Severe Asthma Web\u2010Based Database (SAWD) enrolled 434 participants with severe asthma and a comparison group of 102 participants with non\u2010severe asthma. Published treatable traits were mapped to registry data fields and their prevalence was described. Participants were characterized at baseline and every 6\u2009months for 24\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In SAWD, 24 treatable traits were identified in three domains: pulmonary, extrapulmonary and behavioural\/risk factors. Patients with severe asthma expressed more pulmonary and extrapulmonary treatable traits than non\u2010severe asthma. Allergic sensitization, upper\u2010airway disease, airflow limitation, eosinophilic inflammation and frequent exacerbations were common in severe asthma. Ten traits predicted exacerbation risk; among the strongest were being prone to exacerbations, depression, inhaler device polypharmacy, vocal cord dysfunction and obstructive sleep apnoea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatable traits can be assessed using a severe asthma registry. In severe asthma, patients express more treatable traits than non\u2010severe asthma. Traits may be associated with future asthma exacerbation risk demonstrating the clinical utility of assessing treatable traits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.13389","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T05:24:29Z","timestamp":1537334669000},"page":"37-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":189,"title":["Treatable traits can be identified in a severe asthma registry and predict future exacerbations"],"prefix":"10.1111","volume":"24","author":[{"given":"Vanessa M.","family":"McDonald","sequence":"first","affiliation":[{"name":"Centre of Excellence in Severe Asthma and Priority Research Centre for Healthy Lungs, Faculty of Health University of Newcastle  Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Hiles","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Severe Asthma and Priority Research Centre for Healthy Lungs, Faculty of Health University of Newcastle  Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystelle","family":"Godbout","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Universit\u00e9 Laval  Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin S.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Severe Asthma and Priority Research Centre for Healthy Lungs, Faculty of Health University of Newcastle  Callaghan NSW Australia"},{"name":"Department of Respiratory and Sleep Medicine John Hunter Hospital  New Lambton Heights NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy B.","family":"Marks","sequence":"additional","affiliation":[{"name":"South Western Sydney Clinical School UNSW Sydney  Liverpool NSW Australia"},{"name":"Woolcock Institute of Medical Research The University of Sydney  Glebe NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hew","sequence":"additional","affiliation":[{"name":"Difficult Asthma Clinic, Allergy, Asthma and Clinical Immunology Alfred Health  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine Concord Hospital  Concord NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"Bardin","sequence":"additional","affiliation":[{"name":"Lung and Sleep Medicine Monash University and Medical Centre  Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Lung Research Hanson Institute  Adelaide SA 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