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Patients with these conditions share overlapping disease characteristics, including airway inflammation and airflow limitation. The clinical management of chronic respiratory conditions is increasingly moving away from a one\u2010size\u2010fits\u2010all model based on primary diagnosis, towards care targeting individual disease traits, and is particularly useful for subgroups of patients who respond poorly to conventional therapies. Respiratory microbiome analysis is an important potential contributor to such a \u2018treatable traits\u2019 approach, providing insight into both microbial drivers of airways disease, and the selective characteristics of the changing lower airway environment. We explore the potential to integrate respiratory microbiome analysis into a treatable traits model of clinical care and provide a practical guide to the application and clinical interpretation of respiratory microbiome analysis.<\/jats:p>","DOI":"10.1111\/resp.13411","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T17:50:35Z","timestamp":1538761835000},"page":"19-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The contribution of respiratory microbiome analysis to a treatable traits model of care"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-8243","authenticated-orcid":false,"given":"Steven L.","family":"Taylor","sequence":"first","affiliation":[{"name":"South Australian Health and Medical Research Institute  Adelaide SA Australia"},{"name":"SAHMRI Microbiome Research Laboratory, College of Medicine and Public Health Flinders University  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah E.","family":"O'Farrell","sequence":"additional","affiliation":[{"name":"UQ Thoracic Research Centre, Faculty of Medicine The University of Queensland  Brisbane QLD Australia"},{"name":"Department of Thoracic Medicine The Prince Charles Hospital  Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3626-680X","authenticated-orcid":false,"given":"Jodie L.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Respiratory and Sleep Medicine, Priority Research Centre for Healthy Lungs The University of Newcastle  Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-1993","authenticated-orcid":false,"given":"Ian A.","family":"Yang","sequence":"additional","affiliation":[{"name":"UQ Thoracic Research Centre, Faculty of Medicine The University of Queensland  Brisbane QLD Australia"},{"name":"Department of Thoracic Medicine The Prince Charles Hospital  Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraint B.","family":"Rogers","sequence":"additional","affiliation":[{"name":"South Australian Health and Medical Research Institute  Adelaide SA Australia"},{"name":"SAHMRI Microbiome Research Laboratory, College of Medicine and Public Health Flinders University  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01359-2015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30879-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00476-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00686"},{"key":"e_1_2_7_6_1","unstructured":"National Asthma Council Australia. 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