{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:57:32Z","timestamp":1747187852427,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Obstructive sleep apnoea (OSA) is a prevalent sleep disorder associated with increased cardiovascular morbidity and mortality. Whether treatment of OSA improves cardiovascular risk remains controversial. Our aim was to determine a consensus opinion of key sleep medicine stakeholder groups as to the cardiovascular benefits of treating moderate\u2013severe OSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multidisciplinary panel was assembled from representatives from the Australasian Sleep Association, Sleep Health Foundation, Australasian Sleep Technologists Association, the Sleep Health Foundation Business Council and the Sleep Disorders Australia patient support group. Three statements reflecting areas of controversy related to cardiovascular benefits of OSA treatment were created. A modified RAND\/UCLA appropriateness methodology was applied determining the panel's level of consensus and agreement with each statement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Voting results indicated the panel: (1) remained unsure whether <jats:italic>moderate\u2013severe OSA treatment improves rates of cardiovascular events\/death<\/jats:italic>, (2) agreed that <jats:italic>moderate\u2013severe OSA treatment improves blood pressure in patients with hypertension<\/jats:italic> and (3) mostly agreed <jats:italic>that moderate\u2013severe OSA treatment improves left ventricular function in patients with heart failure<\/jats:italic>. Consensus of opinion was achieved for statements (1) and (2), but was narrowly missed for statement (3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The panel believed that findings from large\u2010scale randomized trials indicate that treatment of moderate\u2013severe OSA has not been established to improve cardiovascular event or morbidity\/mortality rates. Strong evidence supports the ability of treatment to reduce blood pressure. Whilst many panel members believed that treatment improves left ventricular function, some were uncertain of the clinical significance of this secondary endpoint measure derived from lesser quality evidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13413","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T21:14:57Z","timestamp":1538774097000},"page":"376-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A consensus opinion amongst stakeholders as to benefits of obstructive sleep apnoea treatment for cardiovascular health"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9041-3655","authenticated-orcid":false,"given":"Shane A.","family":"Landry","sequence":"first","affiliation":[{"name":"Department of Physiology Monash University  Melbourne VIC Australia"},{"name":"School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences Monash University  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siobhan","family":"Banks","sequence":"additional","affiliation":[{"name":"Behaviour\u2010Brain\u2010Body Research Centre University of South Australia  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Cistulli","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal North Shore Hospital  Sydney NSW Australia"},{"name":"Charles Perkins Centre and Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1744-2839","authenticated-orcid":false,"given":"Garun S.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Medical Centre  Melbourne VIC Australia"},{"name":"School of Clinical Sciences Monash University  Melbourne VIC Australia"},{"name":"Monash Partners \u2013 Epworth  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"H\u00e9raud","sequence":"additional","affiliation":[{"name":"Air Liquide Healthcare  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Kairaitis","sequence":"additional","affiliation":[{"name":"Ludwig Engel Centre for Respiratory Research, Westmead Institute for Medical Research University of Sydney  Sydney NSW Australia"},{"name":"Department of Respiratory and Sleep Medicine, Westmead Hospital University of Sydney  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Lubke","sequence":"additional","affiliation":[{"name":"ResMed  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5021-1648","authenticated-orcid":false,"given":"Sutapa","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Sleep Health Service, Respiratory and Sleep Services Southern Adelaide Local Health Network  Adelaide SA Australia"},{"name":"Adelaide Institute for Sleep Health Flinders University  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teanau","family":"Roebuck","sequence":"additional","affiliation":[{"name":"Department of Allergy, Immunology and Respiratory Medicine Alfred Hospital  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joesph","family":"Soda","sequence":"additional","affiliation":[{"name":"Sleep Disorders Australia  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Umbers","sequence":"additional","affiliation":[{"name":"Philips Sleep and Respiratory Care  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shantha M. 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