{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:52:32Z","timestamp":1760550752145,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CMRPG","award":["391231-3","CMRPG3E1751","NMRPG3B0021","NMRPG3C0041-2"],"award-info":[{"award-number":["391231-3","CMRPG3E1751","NMRPG3B0021","NMRPG3C0041-2"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Pharyngeal distensibility and collapsibility reflect the passive properties of tissue in the airway, are an indicator of the ease with which an airway can be deformed and are related to the severity of obstructive sleep apnoea (OSA). During normal tidal respiration, the collapsibility of the pharynx during expiration is passive without confounding by neuromuscular activation that occurs during inspiration. We evaluated the distensibility and collapsibility of the upper airway in subjects with OSA during wakefulness using sophisticated dynamic computed tomography (CT) imaging. We hypothesized that the dynamic changes of the upper airway during expiration would be related to the severity of OSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010three patients with OSA and eight normal subjects underwent simultaneous measurement of respiratory flow and airway calibre using ultrafast CT. The change in pharyngeal cross\u2010sectional area divided by the change in concomitant flow (as distensibility or collapsibility) was measured and compared across different severities of OSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The slope of this relationship between delta area and delta flow during expiration was significantly higher in severe OSA when compared with normal controls and mild\u2013moderate OSA. Differences in airway distensibility or collapsibility between severity groups were significant in expiration but not in inspiration. Distensibility or collapsibility contributed most to the apnoea\u2013hypopnoea index in regression modelling. Age, gender, and body mass index (BMI) were not significant independent predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates that airway distensibility during the expiratory phase of awake respiration is correlated with the severity of OSA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13474","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T21:35:02Z","timestamp":1548365702000},"page":"582-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pharyngeal distensibility during expiration is an independent predictor of the severity of obstructive sleep apnoea"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-9318","authenticated-orcid":false,"given":"Ning\u2010Hung","family":"Chen","sequence":"first","affiliation":[{"name":"Sleep Center, Department of Pulmonary and Critical Care Medicine Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"Department of Respiratory Therapy Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7915-0014","authenticated-orcid":false,"given":"Shih\u2010Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"Sleep Center, Department of Pulmonary and Critical Care Medicine Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Pang","family":"Chuang","sequence":"additional","affiliation":[{"name":"Sleep Center, Department of Pulmonary and Critical Care Medicine Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-4924","authenticated-orcid":false,"given":"Peter A.","family":"Cistulli","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal North Shore Hospital  Sydney NSW Australia"},{"name":"Charles Perkins Centre, Faculty of Medicine and Health University of Sydney  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng\u2010Jer","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Respiratory Therapy Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Pulmonary and Critical Care Medicine Chang Gung Memorial Hospital  Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Chin","family":"Kao","sequence":"additional","affiliation":[{"name":"Sleep Center, Department of Pulmonary and Critical Care Medicine Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"Department of Respiratory Therapy Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Fang","family":"Liao","sequence":"additional","affiliation":[{"name":"Sleep Center, Department of Craniofacial Orthodontics Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Fu","family":"Li","sequence":"additional","affiliation":[{"name":"Sleep Center, Department of Pulmonary and Critical Care Medicine Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Ta","family":"Yang","sequence":"additional","affiliation":[{"name":"Sleep Center, Department of Pulmonary and Critical Care Medicine Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"Department of Respiratory Therapy Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200404-519OC"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1.62"},{"key":"e_1_2_7_5_1","first-page":"175","article-title":"Prevalence of snoring and witnessed apnea in Taiwanese adults","volume":"31","author":"Chuang LP","year":"2008","journal-title":"Chang Gung Med. 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