{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:17:39Z","timestamp":1780096659883,"version":"3.54.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["Airways Clinical Research Center Award"],"award-info":[{"award-number":["Airways Clinical Research Center Award"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL089510"],"award-info":[{"award-number":["U01 HL089510"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UO1HL089464"],"award-info":[{"award-number":["UO1HL089464"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Obesity produces restrictive effects on lung function. We previously reported that obese patients with asthma exhibit a propensity towards small airway closure during methacholine challenge which improved with weight loss. We hypothesized that increased abdominal adiposity, a key contributor to the restrictive effects of obesity on the lung, mediates this response. This study investigates the effect of body mass index (BMI) versus waist circumference (WC) on spirometric lung function, sensitivity to airway narrowing and closure, and airway closure during bronchoconstriction in patients with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants underwent spirometry and methacholine challenge. Sensitivity to airway closure and narrowing was assessed from the dose\u2013response slopes of the forced vital capacity (FVC) and the ratio of forced expiratory volume in 1\u2009s (FEV<jats:sub>1<\/jats:sub>) to FVC, respectively. Airway closure during bronchoconstriction (closing index) was computed as the percent reduction in FVC divided by the percent reduction in FEV<jats:sub>1<\/jats:sub> at maximal bronchoconstriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 116 asthmatic patients (56 obese) underwent methacholine challenge. Spirometric lung function was inversely related to WC (<jats:italic>P<\/jats:italic> &lt; 0.05), rather than BMI. Closing index increased significantly during bronchoconstriction in obese patients and was related to increasing BMI (<jats:italic>P<\/jats:italic> = 0.01), but not to WC. Sensitivity to airway closure and narrowing was not associated with BMI or WC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although WC is associated with restrictive effects on baseline lung function, increased BMI, rather than WC, predisposes to airway closure during bronchoconstriction. These findings suggest that obesity predisposes to airway closure during bronchoconstriction through mechanisms other than simple mass loading.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13478","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T21:18:30Z","timestamp":1548796710000},"page":"543-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["BMI but not central obesity predisposes to airway closure during bronchoconstriction"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2491-9519","authenticated-orcid":false,"given":"Ubong","family":"Peters","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Vermont Lung Center University of Vermont Larner College of Medicine  Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakumari","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Vermont Lung Center University of Vermont Larner College of Medicine  Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Vermont Lung Center University of Vermont Larner College of Medicine  Burlington VT USA"},{"name":"Translational Airways Group University of Technology  Sydney NSW Australia"},{"name":"Airway Physiology and Imaging Group, Woolcock Institute of Medical Research  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6515-8023","authenticated-orcid":false,"given":"David A.","family":"Kaminsky","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Vermont Lung Center University of Vermont Larner College of Medicine  Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles G.","family":"Irvin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Vermont Lung Center University of Vermont Larner College of Medicine  Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Wise","sequence":"additional","affiliation":[{"name":"Department of Medicine Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen S.","family":"Skloot","sequence":"additional","affiliation":[{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-6377","authenticated-orcid":false,"given":"Jason H.T.","family":"Bates","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Vermont Lung Center University of Vermont Larner College of Medicine  Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Vermont Lung Center University of Vermont Larner College of Medicine  Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1717OC"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.024"},{"key":"e_1_2_9_5_1","unstructured":"MooreWC MeyersDA WenzelSE TeagueWG LiH LiX D'AgostinoR CastroM Curran\u2010EverettD FitzpatrickAMet al.;National Heart Lung and Blood Institute's Severe Asthma Research Program. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program.Am. J. Respir. Crit. Care Med.2010;181:315\u201323."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-076OC"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.12.22"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01267.2009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1976.tb05036.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1960.15.3.377"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104957"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.827"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12368"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00114007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02181-2016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.7.581"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-1-55"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90676-9"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807-1195OC"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0341-y"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0573OC"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0274-5"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.09.016"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152769"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201401-0178OC"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.06.038"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","unstructured":"DixonAE SugarEA ZinreichSJ SlavinRG CorrenJ NaclerioRM IshiiM CohenRI BrownED WiseRAet al.;American Lung Association\u2010Asthma Clinical Research Centers. Criteria to screen for chronic sinonasal disease.Chest2009;136:1324\u201332.","DOI":"10.1378\/chest.08-1983"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.01.011"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.4.998"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.01361.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67402-8"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.ats11-99"},{"key":"e_1_2_9_33_1","unstructured":"MillerMR HankinsonJ BrusascoV BurgosF CasaburiR CoatesA CrapoR EnrightP van derGrintenCP GustafssonPet al.;ATS\/ERS Task Force. Standardisation of spirometry.Eur. Respir. J.2005;26:319\u201338."},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.4.860"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.6.1412"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.07.010"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1039OC"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1980.122.5.781"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01155.2010"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1729"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.1.4"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900600758309"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030501"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.138"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.01.007"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.12.004"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.13478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/resp.13478","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T22:19:21Z","timestamp":1694384361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.13478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,29]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/resp.13478"],"URL":"https:\/\/doi.org\/10.1111\/resp.13478","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,29]]},"assertion":[{"value":"2018-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}