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This has subsequently been addressed by the application of higher levels of pressure support combined with targeted management of chronic respiratory failure, which demonstrated a reduction in all\u2010cause mortality. Similarly, the previous trial of home oxygen therapy (HOT) and HMV delivered following an acute exacerbation failed to demonstrate an improvement in outcome. With the focus on patients with persistent hypercapnic respiratory failure in the recovery phase following a life\u2010threatening exacerbation combined with targeted reduction in carbon dioxide, HOT and HMV (HOT\u2010HMV) was shown to be clinically effective in reducing the time to readmission or death and cost effective in both the United Kingdom and United States healthcare systems. Future work will need to focus on promoting adherence to home ventilation and novel auto\u2010titrating ventilator modes to facilitate and optimize the set\u2010up of overnight ventilatory support in different target population such as COPD patients with obstructive sleep apnoea and COPD patients with episodic nocturnal hypoventilation.<\/jats:p>","DOI":"10.1111\/resp.13484","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T10:52:39Z","timestamp":1549536759000},"page":"732-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Home mechanical ventilation for chronic obstructive pulmonary disease: What next after the HOT\u2010HMV trial?"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4883-0084","authenticated-orcid":false,"given":"Eui\u2010Sik","family":"Suh","sequence":"first","affiliation":[{"name":"Lane Fox Respiratory Service Guy's and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick B.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Lane Fox Respiratory Service Guy's and St Thomas\u2019 NHS Foundation Trust  London UK"},{"name":"Centre for Human and Applied Physiological Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Hart","sequence":"additional","affiliation":[{"name":"Lane Fox Respiratory Service Guy's and St Thomas\u2019 NHS Foundation Trust  London UK"},{"name":"Centre for Human and Applied Physiological Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"StoneRA Holzhauer\u2010BarrieJ LoweD SearleL SkipperE WelhamS RobertsCM. 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