{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:46:23Z","timestamp":1790171183876,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ADIR Association"},{"name":"Canceropole Nord-Ouest"},{"name":"French Ministry of Health - PHRC 2007"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Probe\u2010based confocal laser endomicroscopy (pCLE) enables in vivo microimaging of the distal lung, during bronchoscopy. This study aims at identifying pCLE descriptors of chronic interstitial lung diseases (ILD), their correlations with chest HRCT and assessing inter\u2010observer agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>pCLE was performed in 21 healthy volunteers (HV) and 59 non\u2010smoking ILD patients, including 19 patients with idiopathic pulmonary fibrosis (IPF) or asbestosis, 15 with connective tissue disease\u2010associated ILD (CTD\u2010ILD), 17 with sarcoidosis and 8 with hypersensitivity pneumonitis (HP). pCLE descriptors were identified in ILD on the basis of comparison with HV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine pCLE descriptors were more frequent in ILD compared to HV, with good inter\u2010observer agreement, including fluorescent bronchiolar cells (sarcoidosis, CTD\u2010ILD and HP), fluorescent alveolar cells (CTD\u2010ILD and HP), small alveolar entrance rings (IPF or asbestosis and CTD\u2010ILD), enlarged axial elastic fibres (IPF or asbestosis), septal fibres (IPF or asbestosis, CTD\u2010ILD and HP), disorganized acinar network and rigid acinar network (IPF or asbestosis and CTD\u2010ILD), dense elastic network (IPF or asbestosis) and alveolar fluorescent nodular structures (in sarcoidosis) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, Fisher's exact test, all comparisons). The distribution of nodules on computed tomography (CT) appeared to correlate with pCLE alveolar nodular structures, rigid acinar network and septal fibres, while reticulations were associated with septal fibres and disorganized or dense acinar network; ground\u2010glass opacities on CT with small alveolar entrances, rigid elastic network and septal fibres; and honeycombing with septal fibres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the four groups of ILD studied, 9 pCLE descriptors are described, which appear specific and reproducible, and correlate with chest HRCT patterns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13507","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T15:43:17Z","timestamp":1551282197000},"page":"783-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["In vivo probe\u2010based confocal laser endomicroscopy in chronic interstitial lung diseases: Specific descriptors and correlation with chest CT"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-6396","authenticated-orcid":false,"given":"Mathieu","family":"Sala\u00fcn","sequence":"first","affiliation":[{"name":"Normandie Universit\u00e9 UNIROUEN  Rouen France"},{"name":"Department of Pulmonology and CIC\u2010CRB 1404 Rouen University Hospital  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Guisier","sequence":"additional","affiliation":[{"name":"Normandie Universit\u00e9 UNIROUEN  Rouen France"},{"name":"Department of Pulmonology and CIC\u2010CRB 1404 Rouen University Hospital  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Dominique","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and CIC\u2010CRB 1404 Rouen University Hospital  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Genevois","sequence":"additional","affiliation":[{"name":"Department of Radiology Rouen University Hospital  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Jounieaux","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Bergot","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Caen University Hospital  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Thill","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Rouen University Hospital  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Piton","sequence":"additional","affiliation":[{"name":"Department of Cytology and Pathology Rouen University Hospital  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Thiberville","sequence":"additional","affiliation":[{"name":"Normandie Universit\u00e9 UNIROUEN  Rouen France"},{"name":"Department of Pulmonology and CIC\u2010CRB 1404 Rouen University Hospital  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-147OC"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1420PP"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0801CI"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200605-684OC"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200902-009AW"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00083708"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.129890"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00194509"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00191911"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447431"},{"key":"e_1_2_8_13_1","first-page":"A4316","article-title":"Preliminary observations in the use of confocal alveolar endomicroscopy in recipients of single lung transplantation [Abstract]","volume":"181","author":"Keller C","year":"2010","journal-title":"Am. 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