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However, other possible advantages, which are less appreciated and often poorly studied, may also contribute to the wider use of EBUS\u2010TBNA in the future. These advantages include refinement of differential diagnoses through the study of lymph node characteristics during B\u2010mode examination; reduction of complications associated with bronchoscopy, as well as improved triage of the specimen for ancillary studies with the use of rapid on\u2010site evaluation; optimization of the quality of the sample through the selection of a target area for biopsy with minimal vascularity and absence of calcifications by using the colour Doppler and the B\u2010mode; and prediction of the presence of extensive lymph node fibrosis by using the strain elastography module. Yet, limitations and possible clinical drawbacks should also be acknowledged. Indeed, due to the lack of specificity of the pathology findings in EBUS\u2010derived samples, the diagnosis of sarcoidosis is one of the exclusion and should remain essentially clinical. The external validity of EBUS\u2010TBNA results in sarcoidosis is questionable, as they mainly derive from studies in populations with a high disease prevalence. Finally, the risk exists that the low morbidity and high diagnostic yield of EBUS\u2010TBNA may lead to its overuse in patients with clinical\/radiological findings specific enough to secure a clinical diagnosis of sarcoidosis.<\/jats:p>","DOI":"10.1111\/resp.13537","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T21:09:16Z","timestamp":1553548156000},"page":"531-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Endobronchial ultrasound\u2010guided transbronchial needle aspiration in sarcoidosis: Beyond the diagnostic yield"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-4696","authenticated-orcid":false,"given":"Rocco","family":"Trisolini","sequence":"first","affiliation":[{"name":"Interventional Pulmonology Unit, Policlinico Sant'Orsola University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Baughman","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Cincinnati Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1096-0596","authenticated-orcid":false,"given":"Paolo","family":"Spagnolo","sequence":"additional","affiliation":[{"name":"Section of Respiratory Diseases, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Culver","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.4.482"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948909800412"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.3.709"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10122722"},{"key":"e_1_2_9_6_1","first-page":"217","article-title":"Combining transbronchial aspiration with endobronchial and transbronchial biopsy in sarcoidosis","volume":"54","author":"Bilaceroglu S","year":"1999","journal-title":"Monaldi Arch. 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