{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:05:49Z","timestamp":1792069549565,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004365","name":"Sydney Medical School","doi-asserted-by":"publisher","award":["Australian Postgraduate Award"],"award-info":[{"award-number":["Australian Postgraduate Award"]}],"id":[{"id":"10.13039\/501100004365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>\n                      Sleep\u2010disordered breathing (SDB) has been reported as highly prevalent in idiopathic pulmonary fibrosis (IPF) and other interstitial lung disease (ILD) populations. Nocturnal oxygen desaturation (NOD), or the total sleep time spent with SpoO\n                      <jats:sub>2<\/jats:sub>\n                      &lt; 90% (TST\u2009&lt;\u200990), can occur both with and without associated apnoeas, and is common in ILD. This study aimed to characterize abnormal SDB and extent of TST\u2009&lt;\u200990 in ILD patients and evaluate relationships between TST\u2009&lt;\u200990 and markers of disease severity, development of pulmonary hypertension (PH) and mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive, newly referred ILD patients attending a specialist clinic underwent polysomnography (PSG). Serial lung function tests, echocardiography and other clinical variables were recorded. Predictors of PH and mortality were evaluated using logistic regression and Cox proportional hazards regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 92 ILD patients (including 44 with IPF) underwent PSG. At least mild obstructive sleep apnoea (OSA) was observed in 65.2%, with rapid eye movement (REM)\u2010related events occurring frequently. At least 10% TST\u2009&lt;\u200990 (designated \u2018significant NOD\u2019) was present in 35.9% of patients, and was associated with PH at baseline echocardiography. Multiple indices of hypoxaemia during sleep, including significant NOD, predicted the development of new or worsening PH. TST\u2009&lt;\u200990 predicted overall and progression\u2010free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nocturnal oxygen saturation is associated with poorer prognosis in ILD patients and may contribute towards the pathogenesis of pulmonary vascular disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.13549","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T11:04:15Z","timestamp":1554116655000},"page":"996-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Nocturnal hypoxaemia is associated with adverse outcomes in interstitial lung disease"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-336X","authenticated-orcid":false,"given":"Lauren K.","family":"Troy","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iven H.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1473-0437","authenticated-orcid":false,"given":"Edmund M.T.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith K.H.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendon J.","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Torzillo","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7096-9365","authenticated-orcid":false,"given":"Tamera J.","family":"Corte","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2776"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-010-0336-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.5664\/jcsm.2758","article-title":"Sleep oxygen desaturation predicts survival in idiopathic pulmonary fibrosis","volume":"9","author":"Kolilekas L","year":"2013","journal-title":"J. Clin. Sleep Med."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-013-0834-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200712-1884OC"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.5.7735600"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.41.10.777"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.42.5.353"},{"key":"e_1_2_7_10_1","first-page":"41","article-title":"Elevated nocturnal desaturation index predicts mortality in interstitial lung disease","volume":"29","author":"Corte TJ","year":"2012","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1378"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00089.2014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1240192"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.202"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.4.499"},{"key":"e_1_2_7_19_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.2","author":"Berry RB","year":"2015"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/20.10.844"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034505"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2111053"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00003912"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-578OC"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200302-219OC"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2393"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00173509"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.7.1255"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199201000-00006"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-012-0716-0"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00452-X"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1545OC"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2017.04.010"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200501-017PP"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000163039"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0173"},{"key":"e_1_2_7_38_1","first-page":"27","article-title":"Studies of oxygenation during sleep in patients with interstitial lung disease","volume":"129","author":"Bye PT","year":"1984","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i12.828"},{"key":"e_1_2_7_40_1","first-page":"1221","article-title":"Periodic limb movements during sleep: population prevalence, clinical correlates, and racial differences","volume":"31","author":"Scofield H","year":"2008","journal-title":"Sleep"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-007-9004-3"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(02)00013-8"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.2.179"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.3.1328"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01054.2013"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(82)90026-3"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200707-114MG"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.02.003"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.87.4.432"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1570"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200608-1190PP"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/resp.13549","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.13549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T20:38:27Z","timestamp":1694205507000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.13549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/resp.13549"],"URL":"https:\/\/doi.org\/10.1111\/resp.13549","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2018-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}