{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:32Z","timestamp":1787015912612,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and objective<\/jats:title>\n \n The optimal oxygen supplementation needed to avoid tissue hypoxia in patients with pulmonary hypertension (PH) remains unclear. This study aimed to identify the arterial oxygen tension (PaO\n 2<\/jats:sub>\n ) level needed to avoid tissue hypoxia which results in a poor prognosis in patients with PH.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively analysed the data for 1571 right heart catheterizations in patients suspected of having PH between 1983 and 2017 at our institution. Examinations were classified according to mean pulmonary arterial pressure (mPAP), cardiac index (CI) and the presence of lung disease, pulmonary arterial hypertension (PAH) or chronic thromboembolic PH (CTEPH). The PaO\n 2<\/jats:sub>\n levels needed to avoid tissue hypoxia were compared in each subgroup.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The estimated PaO\n 2<\/jats:sub>\n equivalent to a mixed venous oxygen tension (PvO\n 2<\/jats:sub>\n ) of 35 mm Hg (tissue hypoxia) was 63.2\u2009mm Hg in all patients, 77.0\u2009mm Hg in those with decreased CI (<2.5 L\/min\/m\n 2<\/jats:sup>\n ) and 57.0\u2009mm Hg in those with preserved CI. Multivariate regression analysis identified mPAP, CI and PaO\n 2<\/jats:sub>\n to be independent predictors of extremely low PvO\n 2<\/jats:sub>\n . Similar results were observed regardless of the severity of PH or the presence of lung disease, PAH or CTEPH. The PaO\n 2<\/jats:sub>\n level needed to avoid tissue hypoxia was higher in patients with mild PH and decreased CI than in those with severe PH and preserved CI (70.2 vs 61.5\u2009mm Hg).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These findings indicate that a decreased CI rather than increased mPAP induces tissue hypoxia in PH. Patients with PH and decreased CI may need adjustment of oxygen therapy at higher PaO\n 2<\/jats:sub>\n levels compared with patients with preserved CI.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.13574","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:38:26Z","timestamp":1558053506000},"page":"97-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pulmonary hypertension with a low cardiac index requires a higher PaO\n 2<\/sub>\n level to avoid tissue hypoxia"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-9510","authenticated-orcid":false,"given":"Rika","family":"Suda","sequence":"first","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan"},{"name":"Department of Advanced Medicine in Pulmonary Hypertension, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rintaro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki Jujo","family":"Sanada","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan"},{"name":"Department of Advanced Medicine in Pulmonary Hypertension, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan"},{"name":"Department of Advanced Medicine in Pulmonary Hypertension, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Sakao","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.029"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.5.1547"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","unstructured":"HardingeM AnnandaleJ BourneS CooperB EvansA FreemanD GreenA HippolyteS KnowlesV MacNeeWet al.;British Thoracic Society Home Oxygen Guideline Development Group;British Thoracic Society Standards of Care Committee. 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