{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:09:48Z","timestamp":1787292588975,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["566931"],"award-info":[{"award-number":["566931"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Obstructive sleep apnoea (OSA) and asthma are associated, and nocturnal breathing difficulty that is usually identified as asthma\u2010like symptoms can be present in both conditions. We investigated how nocturnal asthma\u2010like symptoms (NAS) and bronchial hyper\u2010reactivity (BHR) contribute to the association between OSA risk and current asthma, which is currently unknown but a clinically important question.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from 794 middle\u2010aged participants in a population\u2010based cohort who provided information on OSA risk (defined by a STOP\u2010Bang questionnaire score of at least 3), current asthma and NAS, and underwent methacholine bronchial challenge testing. Using regression models, we examined the association between OSA risk and current asthma\u2010NAS subgroups and investigated any effect modification by BHR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The participants were aged 50\u2009years (49.8% male). OSA risk was associated with NAS with or without current asthma (odds ratio (OR): 2.6; 95% CI = 1.3\u20135.0; OR: 4.2; 95% CI = 1.1\u201316.1, respectively), but not with current asthma in the absence of NAS. BHR was associated with current asthma with or without NAS (OR: 2.9; 95% CI = 1.4\u20135.9; OR: 3.4; 95% CI = 2.0\u20137.0, respectively) but not with NAS in the absence of current asthma. The associations between OSA risk and current asthma were neither modified nor mediated by BHR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that some of the nocturnal symptoms perceived as asthma may be OSA symptoms. Patients with nocturnal asthma symptoms should be considered for possible OSA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13576","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T13:27:07Z","timestamp":1557322027000},"page":"1176-1182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Nocturnal symptoms perceived as asthma are associated with obstructive sleep apnoea risk, but not bronchial hyper\u2010reactivity"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-6174","authenticated-orcid":false,"given":"Chamara V.","family":"Senaratna","sequence":"first","affiliation":[{"name":"Allergy and Lung Health, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Melbourne VIC Australia"},{"name":"Department of Community Medicine University of Sri Jayewardenepura  Nugegoda Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Haydn","family":"Walters","sequence":"additional","affiliation":[{"name":"The University of Tasmania  Hobart TAS Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1744-2839","authenticated-orcid":false,"given":"Garun","family":"Hamilton","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences Monash University  Melbourne VIC Australia"},{"name":"Department of Lung and Sleep Monash Health  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Lodge","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Burgess","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bircan","family":"Erbas","sequence":"additional","affiliation":[{"name":"School of Psychology and Public Health La Trobe University  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham G.","family":"Giles","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne VIC Australia"},{"name":"Cancer Epidemiology and Intelligence Division Cancer Council Victoria  Melbourne VIC Australia"},{"name":"Melbourne School of Population and Global Health The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Thomas","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of New South Wales  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9954-0538","authenticated-orcid":false,"given":"Michael J.","family":"Abramson","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5885-0652","authenticated-orcid":false,"given":"Bruce","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Medicine Monash University  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-0615","authenticated-orcid":false,"given":"Jennifer L.","family":"Perret","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamali C.","family":"Dharmage","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.07.002"},{"key":"e_1_2_9_3_1","first-page":"265","article-title":"Obstructive sleep apnea and asthma","volume":"34","author":"Abdul Razak MR","year":"2016","journal-title":"Asian Pac. 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