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Here, we assessed the role of ageing in the early cardiovascular structural remodelling induced by severe CIH in a murine model of OSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cardiovascular remodelling was assessed in young (2\u2009months old, <jats:italic>n<\/jats:italic> = 20) and aged (18\u2009months old, <jats:italic>n<\/jats:italic> = 20) C57BL\/6 female mice exposed to CIH (20% O<jats:sub>2<\/jats:sub> for 40\u2009s, 5% O<jats:sub>2<\/jats:sub> for 20\u2009s) or normoxia (room air) for 8 weeks (6 h\/day).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Early vascular remodelling was observed in young mice exposed to CIH as illustrated by intima\u2010media thickening (mean change: 4.6\u2009\u00b1\u20092.6 \u03bcm; <jats:italic>P<\/jats:italic> = 0.02), elastin fibre disorganization (mean change: 9.2\u2009\u00b1\u20094.5%; <jats:italic>P<\/jats:italic> = 0.02) and fragmentation (mean change: 2.5\u2009\u00b1\u20090.8%; <jats:italic>P<\/jats:italic> = 0.03), and collagen (mean change: 3.2\u2009\u00b1\u20090.6%; <jats:italic>P<\/jats:italic> = 0.001) and mucopolysaccharide accumulation (mean change: 2.4\u2009\u00b1\u20090.8%; <jats:italic>P<\/jats:italic> = 0.01). In contrast, vascular remodelling was not apparent in aged mice exposed to CIH. Furthermore, left ventricular perivascular fibrosis (mean change: 0.71\u2009\u00b1\u20090.1; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and hypertrophy (mean change: 0.17\u2009\u00b1\u20090.1; <jats:italic>P<\/jats:italic> = 0.038) were increased by CIH exposure in young mice, but not in aged mice. Principal component analysis identified similar cardiovascular alterations among the young mice exposed to CIH and both older mouse groups, suggesting that CIH induces premature cardiovascular senescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cardiovascular remodelling induced by severe CIH is affected by the age at which CIH onset occurs, suggesting that the deleterious cardiovascular effects associated with CIH may be more pronounced in younger populations, and such changes resemble chronological age\u2010related declines in cardiovascular structural integrity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13610","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T09:45:03Z","timestamp":1560937503000},"page":"312-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effect of age on the cardiovascular remodelling induced by chronic intermittent 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Lleida University of Lleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Torres","sequence":"additional","affiliation":[{"name":"Laboratori del son, Servei de Pneumologia Hospital Cl\u00ednic  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Almendros","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES)  Madrid Spain"},{"name":"Unitat de Biof\u00edsica i Bioenginyeria, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Farre","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES)  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