{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:51:18Z","timestamp":1778356278348,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ResMed"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Increases in Cheyne\u2013Stokes respiration (CSR) cycle length (CL), lung\u2010to\u2010periphery circulation time (LPCT) and time to peak flow (TTPF) may reflect impaired cardiac function. This retrospective analysis used an automatic algorithm to evaluate baseline CSR\u2010related features and then determined whether these could be used to identify patients with systolic heart failure (HF) who experienced serious adverse events in the Treatment of Sleep\u2010Disordered Breathing with Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients with Heart Failure (SERVE\u2010HF) substudy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 280 patients had overnight diagnostic polysomnography data available; an automated algorithm was applied to quantify CSR\u2010related features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median baseline CL, LPCT and TTPF were similar in the control (<jats:italic>n<\/jats:italic> = 152) and adaptive servo\u2010ventilation (ASV, <jats:italic>n<\/jats:italic> = 156) groups. In both groups, CSR\u2010related features were significantly longer in patients who did (<jats:italic>n<\/jats:italic> = 129) versus did not (<jats:italic>n<\/jats:italic> = 140) experience a primary endpoint event (all\u2010cause death, life\u2010saving cardiovascular intervention or unplanned hospitalization for worsening HF): CL, 61.1 versus 55.1\u2009s (<jats:italic>P<\/jats:italic> = 0.002); LPCT, 36.5 versus 31.5\u2009s (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001); TTPF, 15.20 versus 13.35\u2009s (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), respectively. This finding was independent of treatment allocation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with systolic HF and central sleep apnoea who experienced serious adverse events had longer CSR CL, LPCT and TTPF. Future studies should examine an independent role for CSR\u2010related features to enable risk stratification in systolic HF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13613","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T08:20:04Z","timestamp":1561018804000},"page":"305-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association of serious adverse events with Cheyne\u2013Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE\u2010Heart Failure substudy analysis"],"prefix":"10.1111","volume":"25","author":[{"given":"Faizan","family":"Javed","sequence":"first","affiliation":[{"name":"Clinical Science and Innovation ResMed Asia Pacific Ltd  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Tamisier","sequence":"additional","affiliation":[{"name":"Pole Thorax et Vaisseaux CHU Grenoble\u2010Alpes  Grenoble France"},{"name":"Laboratoire HP2 Inserm Universit\u00e9 Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-2358","authenticated-orcid":false,"given":"Jean\u2010Louis","family":"Pepin","sequence":"additional","affiliation":[{"name":"Pole Thorax et Vaisseaux CHU Grenoble\u2010Alpes  Grenoble France"},{"name":"Laboratoire HP2 Inserm Universit\u00e9 Grenoble\u2010Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin R.","family":"Cowie","sequence":"additional","affiliation":[{"name":"Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Wegscheider","sequence":"additional","affiliation":[{"name":"Department of Medical Biometry and Epidemiology University Medical Center Eppendorf  Hamburg 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