{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:15:19Z","timestamp":1790691319709,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201012\u2010TECS\u20100010"],"award-info":[{"award-number":["ANR\u201012\u2010TECS\u20100010"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201015\u2010IDEX\u201002"],"award-info":[{"award-number":["ANR\u201015\u2010IDEX\u201002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012019","name":"Fondation du Souffle","doi-asserted-by":"publisher","award":["SRC_2017"],"award-info":[{"award-number":["SRC_2017"]}],"id":[{"id":"10.13039\/100012019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Continuous positive airway pressure (CPAP) is the first\u2010line therapy for obstructive sleep apnoea (OSA). Residual apnoea and\/or hypopnoea events, that is an apnoea\u2013hypopnoea index (AHI)\u2009&gt; 5, during CPAP contribute to treatment drop\u2010out. The clinical scenarios triggering residual events during CPAP use are poorly described. Underlying co\u2010morbidities, especially cardiovascular diseases, lifestyle factors, OSA characteristics at diagnosis and type of mask have been suggested as potential contributors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients from the prospective French sleep apnoea registry diagnosed with OSA (AHI\u2009\u2265\u200915 events\/h) treated with CPAP were included. Logistic regression analysis identified factors associated with a risk of residual AHI\u2009&gt; 5 events\/h on CPAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 12\u2009285 OSA patients were predominantly men (<jats:italic>n<\/jats:italic> =\u20098715, 70.9%), middle\u2010aged (58.2 (49.8; 66.1) years) and obese (median body mass index: 31.3 (27.7; 35.6) kg\/m<jats:sup>2<\/jats:sup>). Most had an AHI\u2009\u2264 5 events\/h (<jats:italic>n<\/jats:italic> = 9573, 77.9%) versus 22.1% with AHI\u2009&gt; 5\/h. The latter were less CPAP adherent (5.75 (4.01; 7.00) vs 6.00 (4.53; 7.00) h\/night). In multivariable analysis, factors associated with residual AHI &gt;5\/h were male sex, age, sedentary lifestyle, OSA severity, cardiovascular co\u2010morbidities (heart failure and arrhythmia) and type of interface (orofacial mask versus nasal mask: OR = 2.15 (95%CI: 1.95; 2.37)). A subgroup analysis found that patients using pressures above 10 cm\u2009H<jats:sub>2<\/jats:sub>O were 1.43 (95% CI: 1.3; 1.57) times more likely to have residual AHI\u2009&gt; 5\/h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Knowing about risk factors for residual apnoeic\u2013hypopnoeic events may assist in the timely provision of personalized care including the type of PAP therapy, attention to co\u2010morbidities and choice of interface.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13650","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T23:53:01Z","timestamp":1563925981000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Partial failure of CPAP treatment for sleep apnoea: Analysis of the French national sleep database"],"prefix":"10.1111","volume":"25","author":[{"given":"S\u00e9bastien","family":"Bailly","sequence":"first","affiliation":[{"name":"HP2 Laboratory, INSERM U1042 Grenoble Alpes University  Grenoble France"},{"name":"EFCR Laboratory Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najeh","family":"Daabek","sequence":"additional","affiliation":[{"name":"HP2 Laboratory, INSERM U1042 Grenoble Alpes University  Grenoble France"},{"name":"AGIR \u00e0 dom, Non\u2010Profit Homecare Organisation  Meylan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-597X","authenticated-orcid":false,"given":"Ingrid","family":"Jullian\u2010Desayes","sequence":"additional","affiliation":[{"name":"HP2 Laboratory, INSERM U1042 Grenoble Alpes University  Grenoble France"},{"name":"EFCR Laboratory Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Joyeux\u2010Faure","sequence":"additional","affiliation":[{"name":"HP2 Laboratory, INSERM U1042 Grenoble Alpes University  Grenoble France"},{"name":"EFCR Laboratory Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Sap\u00e8ne","sequence":"additional","affiliation":[{"name":"Private Practice Sleep and Respiratory Disease Centre Nouvelle Clinique Bel Air  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Grillet","sequence":"additional","affiliation":[{"name":"Private Practice Sleep and Respiratory Disease Centre  Valence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4140-6210","authenticated-orcid":false,"given":"Jean\u2010Christian","family":"Borel","sequence":"additional","affiliation":[{"name":"HP2 Laboratory, INSERM U1042 Grenoble Alpes University  Grenoble France"},{"name":"EFCR Laboratory Grenoble Alpes University Hospital  Grenoble France"},{"name":"AGIR \u00e0 dom, Non\u2010Profit Homecare Organisation  Meylan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Tamisier","sequence":"additional","affiliation":[{"name":"HP2 Laboratory, INSERM U1042 Grenoble Alpes University  Grenoble France"},{"name":"EFCR Laboratory Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-2358","authenticated-orcid":false,"given":"Jean\u2010Louis","family":"P\u00e9pin","sequence":"additional","affiliation":[{"name":"HP2 Laboratory, INSERM U1042 Grenoble Alpes University  Grenoble France"},{"name":"EFCR Laboratory Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.15"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)00054-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210431"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210943"},{"key":"e_1_2_10_6_1","unstructured":"McEvoyRD AnticNA HeeleyE LuoY OuQ ZhangX MedianoO ChenR DragerLF LiuZet al.;SAVE Investigators and Coordinators. 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