{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:22:55Z","timestamp":1780492975158,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["HX002263\u201001A1"],"award-info":[{"award-number":["HX002263\u201001A1"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>\n<jats:italic>Enterobacteriaceae<\/jats:italic> (EB) spp. family is known to include potentially multidrug\u2010resistant (MDR) microorganisms, and remains as an important cause of community\u2010acquired pneumonia (CAP) associated with high mortality. The aim of this study was to determine the prevalence and specific risk factors associated with EB and MDR\u2010EB in a cohort of hospitalized adults with CAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a multinational, point\u2010prevalence study of adult patients hospitalized with CAP. MDR\u2010EB was defined when \u22653 antimicrobial classes were identified as non\u2010susceptible. Risk factors assessment was also performed for patients with EB and MDR\u2010EB infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 3193 patients enrolled with CAP, 197 (6%) had a positive culture with EB. Fifty\u2010one percent (<jats:italic>n<\/jats:italic> = 100) of EB were resistant to at least one antibiotic and 19% (<jats:italic>n<\/jats:italic> = 38) had MDR\u2010EB. The most commonly EB identified were <jats:italic>Klebsiella pneumoniae<\/jats:italic> (<jats:italic>n<\/jats:italic> = 111, 56%) and <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>n<\/jats:italic> = 56, 28%). The risk factors that were independently associated with EB CAP were male gender, severe CAP, underweight (body mass index (BMI)\u2009&lt;\u200918.5) and prior extended\u2010spectrum beta\u2010lactamase (ESBL) infection. Additionally, prior ESBL infection, being underweight, cardiovascular diseases and hospitalization in the last 12\u2009months were independently associated with MDR\u2010EB CAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study of adults hospitalized with CAP found a prevalence of EB of 6% and MDR\u2010EB of 1.2%, respectively. The presence of specific risk factors, such as prior ESBL infection and being underweight, should raise the clinical suspicion for EB and MDR\u2010EB in patients hospitalized with CAP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13663","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:28:27Z","timestamp":1565051307000},"page":"543-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Prevalence and risk factors for <i>Enterobacteriaceae<\/i> in patients hospitalized with community\u2010acquired pneumonia"],"prefix":"10.1111","volume":"25","author":[{"given":"David","family":"Villafuerte","sequence":"first","affiliation":[{"name":"Division of Pulmonary Diseases and Critical Care Medicine University of Texas Health \u2013 San Antonio  San Antonio TX USA"},{"name":"Division of Pulmonary Diseases and Critical Care Medicine South Texas Veterans Health Care System  San Antonio TX 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