{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:09:14Z","timestamp":1791212954985,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>We hypothesized that by reducing respiratory work and improving gas exchange, nasal high flow (NHF) would improve exercise tolerance in patients with chronic obstructive pulmonary disease (COPD) following respiratory exacerbation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a monocentric, randomized, controlled crossover study. Patients with severe to very severe COPD carried out two high\u2010intensity constant work\u2010rate exercise tests (CWRET) with and without NHF on two consecutive days. The primary outcome was the mean difference in endurance time between both conditions. The secondary aims included <jats:italic>vastus lateralis<\/jats:italic> oxygenation (StO<jats:sub>2<\/jats:sub>), dyspnoea, leg discomfort, maximal inspiratory pressure (MIP), transcutaneous CO<jats:sub>2<\/jats:sub> pressure (PtcCO<jats:sub>2<\/jats:sub>), respiratory rate (RR), heart rate (HR) and pulsed O<jats:sub>2<\/jats:sub> saturation (SpO<jats:sub>2<\/jats:sub>), as well as the patients' opinions of the device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 19 patients were included (mean forced expiratory volume in 1\u2009s = 28.7\u2009\u00b1\u200910.8%, age = 62.1\u2009\u00b1\u20099.1 years). No significant differences in endurance time during the CWRET were found between the two test conditions (\u221266.58 (95% CI: \u2212155.9 to 22.7) s, <jats:italic>P<\/jats:italic> = 0.12). StO<jats:sub>2<\/jats:sub>, PtCO<jats:sub>2<\/jats:sub> and HR were reduced at the end of the exercise with NHF (\u22122.1% (95% CI: \u22124.3 to \u22120.0); \u22121.3\u2009mm Hg (95% CI: \u22122.5 to \u22120.2); \u22122.7 bpm (95% CI: \u22125.0 to \u22120.5), respectively, <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.05). No significant differences were found for any of the other secondary outcomes. Half of the patients evaluated the device as being moderately to very uncomfortable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NHF during exercise did not increase endurance time in patients with COPD following exacerbation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p>NCT03058081 at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13664","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T23:45:08Z","timestamp":1565135108000},"page":"1088-1094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Nasal high flow does not improve exercise tolerance in COPD patients recovering from acute exacerbation: A randomized crossover study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2859-2696","authenticated-orcid":false,"given":"Guillaume","family":"Prieur","sequence":"first","affiliation":[{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), P\u00f4le de Pneumologie, ORL and Dermatologie, Groupe de Recherche en Kin\u00e9sith\u00e9rapie Respiratoire Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Institute for Research and Innovation in Biomedicine (IRIB) Normandie University, UNIROUEN  Rouen France"},{"name":"Pulmonology Department Groupe Hospitalier du Havre  Montivilliers France"},{"name":"Pulmonary Rehabilitation Department Groupe Hospitalier du Havre  Montivilliers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Medrinal","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Biomedicine (IRIB) Normandie University, UNIROUEN  Rouen 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Clinique (IREC), P\u00f4le de Pneumologie, ORL and Dermatologie, Groupe de Recherche en Kin\u00e9sith\u00e9rapie Respiratoire Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Service de Pneumologie Cliniques Universitaires Saint\u2010Luc  Brussels 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