{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:47:02Z","timestamp":1769608022844,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R34HL138235"],"award-info":[{"award-number":["R34HL138235"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["234\u20102005\u2010370011C"],"award-info":[{"award-number":["234\u20102005\u2010370011C"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Disease\u2010specific outcomes following lung transplantation (LT) in patients with pulmonary Langerhans cell histiocytosis (PLCH) are not well established. We queried the Organ Procurement and Transplantation Network database to identify adult PLCH patients who had undergone LT in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall survival data were analysed with Kaplan\u2013Meier curves. Cox proportional hazard model was used to determine the effect of demographic, clinical and physiological variables on post\u2010transplant survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 87 patients with PLCH underwent LT in the United States between October 1987 and June 2017, accounting for 0.25% of the total LT during this period. The mean age at LT for PLCH patients was 49\u2009years (range: 19\u201367\u2009years), with a near equal gender distribution. Bilateral sequential LT was performed in 71 patients (82%). Pulmonary hypertension was present in 85% of patients, with a mean pulmonary artery pressure of 38.5 \u00b1\u200914.1\u2009mm Hg. The mean pre\u2010transplant forced expiratory volume in 1\u2009s (FEV<jats:sub>1<\/jats:sub>) was 41 \u00b1\u200921% predicted and the mean 6\u2010min walk distance was 221\u2009\u00b1\u2009111 m. Median post\u2010LT survival for PLCH patients was comparable to patients with other lung diseases (5.1 vs 5.5\u2009years, <jats:italic>P<\/jats:italic> = 0.76). The actuarial Kaplan\u2013Meier post\u2010LT survival for PLCH patients was 85%, 65%, 49% and 22% at 1, 3, 5 and 10\u2009years, respectively. Female sex (hazard ratio (HR): 0.40, 95% CI: 0.22\u20130.72), pre\u2010transplant serum bilirubin (HR: 1.66, 95% CI: 1.23\u20132.26) and serum creatinine (HR: 4.03, 95% CI: 1.01\u201314.76) were independently associated with post\u2010LT mortality in our cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Post\u2010LT survival in patients with PLCH is similar to patients with other lung diseases and is significantly affected by patient gender.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13671","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:09:10Z","timestamp":1565654950000},"page":"644-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical outcomes and survival following lung transplantation in patients with pulmonary Langerhans cell histiocytosis"],"prefix":"10.1111","volume":"25","author":[{"given":"Nikolai","family":"Wajda","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine University of Cincinnati Medical Center  Cincinnati OH USA"},{"name":"Medical Service Department of Veterans Affairs  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health University of Cincinnati  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Jandarov","sequence":"additional","affiliation":[{"name":"Department of Environmental Health University of Cincinnati  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel F.","family":"Dilling","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Loyola University Chicago, Stritch School of Medicine  Maywood IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9112-1315","authenticated-orcid":false,"given":"Nishant","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine University of Cincinnati Medical Center  Cincinnati OH USA"},{"name":"Medical Service Department of Veterans Affairs  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14562"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"YusenRD EdwardsLB DipchandAI GoldfarbSB KucheryavayaAY LevveyBJ LundLH MeiserB RossanoJW StehlikJ;International Society for Heart and Lung Transplantation. 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