{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:08:30Z","timestamp":1786504110364,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","award":["Bridging Grant"],"award-info":[{"award-number":["Bridging Grant"]}],"id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Fixed airflow obstruction (FAO) in asthma occurs despite optimal inhaled treatment and no smoking history, and remains a significant problem, particularly with increasing age and duration of asthma. Increased lung compliance and loss of lung elastic recoil has been observed in older people with asthma, but their link to FAO has not been established. We determined the relationship between abnormal lung elasticity and airflow obstruction in asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Non\u2010smoking asthmatic subjects aged &gt;40\u2009years, treated with 2\u2009months of high\u2010dose inhaled corticosteroid\/long\u2010acting beta\u2010agonist (ICS\/LABA), had FAO measured by spirometry, and respiratory system resistance at 5\u2009Hz (Rrs<jats:sub>5<\/jats:sub>) and respiratory system reactance at 5\u2009Hz (Xrs<jats:sub>5<\/jats:sub>) measured by forced oscillation technique. Lung compliance (K) and elastic recoil (B\/A) were calculated from pressure\u2013volume curves measured by an oesophageal balloon. Linear correlations between K and B\/A, and forced expiratory volume in 1\u2009s\/forced vital capacity (FEV<jats:sub>1<\/jats:sub>\/FVC), Rrs<jats:sub>5<\/jats:sub> and Xrs<jats:sub>5<\/jats:sub> were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen subjects (11 males; mean\u2009\u00b1 SD age: 64\u2009\u00b1\u20098\u2009years, asthma duration: 39\u2009\u00b1\u200922\u2009years) had moderate FAO measured by spirometry ((mean\u2009\u00b1 SD z\u2010score) post\u2010bronchodilator FEV<jats:sub>1<\/jats:sub>: \u22122.2 \u00b1\u20090.5, FVC: \u22120.7 \u00b1\u20091.0, FEV<jats:sub>1<\/jats:sub>\/FVC: \u22122.6 \u00b1\u20090.7) and by increased Rrs<jats:sub>5<\/jats:sub> (median (IQR) z\u2010score) 2.7 (1.9 to 3.2) and decreased Xrs<jats:sub>5<\/jats:sub>: \u22124.1(\u22122.4 to \u22127.3). Lung compliance (K) was increased in 9 of 18 subjects and lung elastic recoil (B\/A) reduced in 5 of 18 subjects. FEV<jats:sub>1<\/jats:sub>\/FVC correlated negatively with K (r<jats:sub>s<\/jats:sub> =\u2009\u22120.60, <jats:italic>P<\/jats:italic> =\u20090.008) and Rrs<jats:sub>5<\/jats:sub> correlated negatively with B\/A (r<jats:sub>s<\/jats:sub> =\u2009\u22120.52, <jats:italic>P<\/jats:italic> =\u20090.026), independent of age. Xrs<jats:sub>5<\/jats:sub> did not correlate with lung elasticity indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased lung compliance and loss of elastic recoil relate to airflow obstruction in older non\u2010smoking asthmatic subjects, independent of ageing. Thus, structural lung tissue changes may contribute to persistent, steroid\u2010resistant airflow obstruction.Clinical trial registration: ACTRN126150000985583 at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.anzctr.org.au\">anzctr.org.au<\/jats:ext-link> (UTN: U1111\u20101156\u20102795)<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13688","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:58:36Z","timestamp":1567558716000},"page":"613-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Reduced lung elastic recoil and fixed airflow obstruction in asthma"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8594-366X","authenticated-orcid":false,"given":"Katrina O.","family":"Tonga","sequence":"first","affiliation":[{"name":"The Department of Respiratory Medicine Royal North Shore Hospital  Sydney NSW 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