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NEA was classified as baseline blood eosinophils &lt;0.26\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L and FENO \u226429\u2009ppb. Exacerbations requiring medical intervention were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 220 non\u2010smokers (<jats:italic>n<\/jats:italic> = 109 control, <jats:italic>n<\/jats:italic> = 111 FENO), 1006 treatment decisions were made, with significant group differences after the first and second algorithm applications. 53% of women had NEA. Treatment was better targeted to phenotype in the FENO group: ICS use increased in eosinophilic asthma (EA, 48\u201386%), while ICS\/LABA increased in NEA (11\u201330%). Fewer women in the FENO group had exacerbations during pregnancy in NEA only (18.9% FENO vs 44% control, <jats:italic>P<\/jats:italic> = 0.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The FENO algorithm was more effective in treating NEA, resulting in reduced exacerbations, compared to a symptom control algorithm. This was not the result of ICS overtreatment, since the benefits occurred at a lower median daily ICS dose. Two applications of the FENO\u2010guided algorithm, one month apart, were sufficient to achieve beneficial effects in terms of asthma exacerbations, among pregnant women with asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13713","type":"journal-article","created":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T00:15:06Z","timestamp":1572135306000},"page":"719-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Biomarker\u2010guided management reduces exacerbations in non\u2010eosinophilic asthma in pregnancy: A secondary analysis of a randomized controlled trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3282-1324","authenticated-orcid":false,"given":"Vanessa E.","family":"Murphy","sequence":"first","affiliation":[{"name":"Priority Research Centre GrowUpWell and Hunter Medical Research Institute, Faculty of Health and Medicine The University of Newcastle  Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4825-9436","authenticated-orcid":false,"given":"Celeste M.","family":"Porsbjerg","sequence":"additional","affiliation":[{"name":"Respiratory Research Unit, Department of Respiratory Medicine Bispebjerg University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies L.","family":"Robijn","sequence":"additional","affiliation":[{"name":"Priority Research Centre GrowUpWell and Hunter Medical Research Institute, Faculty of Health and Medicine The University of Newcastle  Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5865-489X","authenticated-orcid":false,"given":"Peter G.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs and Hunter Medical Research Institute, Faculty of Health and Medicine The University of Newcastle  Callaghan NSW Australia"},{"name":"Department of Respiratory and Sleep Medicine John Hunter Hospital  Newcastle NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01813-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11679-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871524915666150710123415"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60971-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201109-1640OC"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.7.643"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2011.01312.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.124941"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.049718"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00195111"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203388"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.039"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01882-2015"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03226.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12345"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14d29.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.08.012"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001802"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.04.046"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-211540"},{"key":"e_1_2_10_23_1","first-page":"CD011440","article-title":"Exhaled nitric oxide levels to guide treatment for adults with asthma","volume":"9","author":"Petsky HL","year":"2016","journal-title":"Cochrane Database Syst. 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