{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:31:21Z","timestamp":1774510281099,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T00:00:00Z","timestamp":1577145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>OSA and PLMS are known to induce acute BP swings during sleep. Our current study aimed to address the independent effect of PLMS on BP in an unselected OSA patient cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional analysis included 1487 patients (1110 males, no previous hypertension diagnosis or treatment, mean age: 52.5\u2009years, mean BMI: 30.5\u2009kg\/m<jats:sup>2<\/jats:sup>) with significant OSA (defined as AHI\u2009\u2265\u200910) recruited from the European Sleep Apnoea Cohort. Patients underwent overnight PSG. Patients were stratified into two groups: patients with significant PLMS (PLMSI\u2009&gt;\u200925 events\/hour of sleep) and patients without significant PLMS (PLMSI\u2009&lt;\u200925 events\/hour of sleep). SBP, DBP and PP were the variables of interest. For each of these, a multivariate regression linear model was fitted to evaluate the relationship between PLMS and outcome adjusting for sociodemographic and clinical covariates (gender, age, BMI, AHI, ESS, diabetes, smoking and sleep efficiency).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The univariate analysis of SBP showed an increment of BP equal to 4.70\u2009mm Hg (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in patients with significant PLMS compared to patients without significant PLMS. This increment remained significant after implementing a multivariate regression model (2.64\u2009mm Hg, <jats:italic>P<\/jats:italic> = 0.044). No significant increment of BP was observed for DBP and PP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PLMS is associated with a rise in SBP regardless of AHI, independent of clinical and sociodemographic confounders. A PLMS phenotype may carry an increased risk for cardiovascular disease in OSA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13760","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T09:04:09Z","timestamp":1577178249000},"page":"872-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-6053","authenticated-orcid":false,"given":"Carolina","family":"Lombardi","sequence":"first","affiliation":[{"name":"Sleep Disorders Center, Department of Cardiovascular, Neural and Metabolic Sciences San Luca Hospital, Instituto Auxologico Italiano, IRCCS  Milan Italy"},{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Parati","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center, Department of Cardiovascular, Neural and Metabolic Sciences San Luca Hospital, Instituto Auxologico Italiano, IRCCS  Milan Italy"},{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Soranna","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center, Department of Cardiovascular, Neural and Metabolic Sciences San Luca Hospital, Instituto Auxologico Italiano, IRCCS  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Zambon","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center, Department of Cardiovascular, Neural and Metabolic Sciences San Luca Hospital, Instituto Auxologico Italiano, IRCCS  Milan Italy"},{"name":"Department of Statistics and Quantitative Methods University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Sliwinski","sequence":"additional","affiliation":[{"name":"Second Department of Respiratory Medicine Institute of Tuberculosis and Lung Diseases  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Roisman","sequence":"additional","affiliation":[{"name":"Sleep Medicine Unit at H\u00f4pital B\u00e9cl\u00e8re H\u00f4pitaux Universitaires Paris\u2010Sud  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-2358","authenticated-orcid":false,"given":"Jean\u2010Louis","family":"Pepin","sequence":"additional","affiliation":[{"name":"HP2 Laboratory, INSERM U1042 University Grenoble Alpes  Grenoble France"},{"name":"EFCR Laboratory, Pole Thorax et Vaisseaux Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Schiza","sequence":"additional","affiliation":[{"name":"Sleep Disorders Unit, Department of Respiratory Medicine, Medical School University of Crete  Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Riha","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences, Sleep Research Unit, Department of Sleep Medicine Royal Infirmary of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavol","family":"Joppa","sequence":"additional","affiliation":[{"name":"University Hospital L. 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